Publications by authors named "Morten Haaning Charles"
Endocr Connect
March 2023
Article Synopsis
- - PAPP-A, an enzyme involved in breaking down IGF-binding proteins, has been linked to an increased risk of cardiovascular disease (CVD) and higher all-cause mortality in patients with type 2 diabetes (T2D), specifically in a study of 1284 participants over 5 years.
- - The study found that higher levels of STC2 and PAPP-A, as well as IGFBP4, correlate with increased mortality rates, while lower levels of IGF1 are associated with higher mortality.
- - The findings suggest that while PAPP-A contributes to CVD risk and mortality, STC2 might act as a counterbalance to its harmful effects or have independent impacts beyond the PAPP-A-
