Publications by authors named "Morten Fjorback"
Boron-doped nanocrystalline diamond (BDD) electrodes have recently attracted attention as materials for neural electrodes due to their superior physical and electrochemical properties, however their biocompatibility remains largely unexplored. In this work, we aim to investigate the in vivo biocompatibility of BDD electrodes in relation to conventional titanium nitride (TiN) electrodes using a rat subcutaneous implantation model. High quality BDD films were synthesized on electrodes intended for use as an implantable neurostimulation device.
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- The study examined how fibrous encapsulation impacts the electrochemical properties of porous titanium nitride electrodes in a living organism (in vivo).
- Electrochemical impedance spectroscopy (EIS) was used to monitor inflammation and healing, revealing that the encapsulation lasted 3-4 weeks, during which voltage transients (VTs) increased and charge storage capacity (CSC) decreased.
- The findings suggest that the changes in VTs and CSC are linked to the healing process, and that traditional methods may underestimate the limits of charge injection during encapsulation.
The in vivo electrochemical behavior of titanium nitride (TiN) nerve stimulation electrodes was compared to their in vitro behavior for a period of 90 days. Ten electrodes were implanted in two Göttingen minipigs. Four of these were used for electrical stimulation and electrochemical measurements.
View Article and Find Full Text PDFObjectives: The aim of this study was to investigate whether acute electrical stimulation of the posterior tibial nerve could suppress detrusor contractions in multiple sclerosis (MS) patients with neurogenic detrusor overactivity.
Methods: Two successive slow-fill cystometries (16 ml/min) were carried out in eight MS patients with neurogenic detrusor overactivity. The first filling served as control without stimulation.
Aims: The aim of this study was to evaluate the effect of automatic event driven electrical stimulation on the dorsal penile/clitoral nerve for management of neurogenic detrusor overactivity in patients suffering from Multiple Sclerosis.
Methods: A total of 10 patients participated in the study. Detrusor pressure was recorded during physiological filling of the bladder and electrical stimulation was applied with surface electrodes whenever the detrusor pressure exceeded 10 cm H(2)O.