Publications by authors named "Morten F Lukacs"
Background: We have previously sequenced more than 500 kb of the duplicated MHC class I regions in Atlantic salmon. In the IA region we identified the loci for the MHC class I gene Sasa-UBA in addition to a soluble MHC class I molecule, Sasa-ULA. A pseudolocus for Sasa-UCA was identified in the nonclassical IB region.
View Article and Find Full Text PDFBackground: In teleosts, the Major Histocompatibility Complex (MHC) class I and class II molecules reside on different linkage groups as opposed to tetrapods and shark, where the class I and class II genes reside in one genomic region. Several teleost MHC class I regions have been sequenced and show varying number of class I genes. Salmonids have one major expressed MHC class I locus (UBA) in addition to varying numbers of non-classical genes.
View Article and Find Full Text PDFArticle Synopsis
- Researchers sequenced over 500 kb of two duplicated MHC class I regions in Atlantic salmon to study their role in resistance to pathogens.
- The gene organization revealed several proteasome components and a recently identified MHC class I locus (Sasa-ULA), along with extensive differences in gene content between Atlantic salmon and rainbow trout.
- The findings suggest significant rearrangements in the MHC class IB region between these species, highlighting the need for further sequencing of salmon to understand its immune system better.