Integrating Neural Substrates, Diabetes Self-Management, and Behavior Change for Tailored Lifestyle Interventions in Type-2 Diabetes: A Neurobehavioral Perspective.

Understanding the neural mechanisms that underlie behavior change is critical for improving lifestyle management in type 2 diabetes. Individuals with type 2 diabetes face unique challenges in adopting and maintaining healthy behaviors, which can be influenced by alterations in brain function and plasticity, potentially leading to cognitive impairment. Diabetes self-management education and support (DSMES) programs aim to enhance lifestyle changes and promote better health outcomes while reducing cognitive decline.

Global approaches to older abuse research in institutional care settings: A systematic review.

Background: Over the last two decades, abuse of older adults in institutional settings has been underestimated due to challenges in defining and responding to the issue. This systematic review aims to analyze empirical studies on measuring abuse of older people residing in a long-term care facility, specifically staff-to-resident abuse.

Methods: Following PRISMA guidelines, we searched 10 databases from January 2005 till June 2024.

From genetic disposition to academic achievement: The mediating role of non-cognitive skills across development.

Genetic effects on academic achievement are likely to capture environmental, developmental, and psychological processes. How these processes contribute to translating genetic dispositions into observed academic achievement remains critically under-investigated. Here, we examined the role of non-cognitive skills-e.

Missed opportunities to manage complex comorbidity of heart failure, type 2 diabetes mellitus and chronic kidney disease: a retrospective cohort study.

Background: Effective management of coexisting heart failure (HF), chronic kidney disease (CKD) and type 2 diabetes mellitus (T2D) is critical, yet evidence of adherence to guideline-recommended standards in routine care remains unclear. We aimed to assess primary care adherence to guideline-recommended standards for patients with overlapping HF, CKD and T2D in England.

Methods: Using UK Clinical Practice Research Datalink (1998-2020), we evaluated care adherence across 161 529 individuals with HF, CKD or T2D before and after developing a second of these conditions.

A technology-based randomized controlled trial of self-affirmation and gain-framed health messaging to reduce sedentary behavior in older adults.

Objective: Sedentary behavior significantly increases the risk for chronic diseases and cognitive decline in aging, underscoring the need for effective interventions. Older adults exhibit a 'positivity effect', whereby processing of positive information is prioritized over negative information. In addition, self-affirmation was shown to reduce sedentary behavior in younger adults, but its effects in older adults remain unknown.

Genetic contributions to the educational inequalities in coronary heart disease incidence: a population-based study of 32 000 middle-aged men and women.

Background: The background of educational disparities in coronary heart disease (CHD) risk is still not well understood. We used a polygenic score for education (PGS), socioeconomic indicators and indicators of CHD risk to investigate whether these disparities result from causality or are influenced by shared factors.

Methods: Population-based health surveys including baseline measures on cardiometabolic risk factors at 25-70 years of age (N=32 610) and PGS were conducted in Finland between 1992 and 2011.

Delays and Discrepancies in the Care of Older Injured Patients Across the United Kingdom: A Cohort Study.

Introduction The average age of patients undergoing orthopaedic trauma surgery increases with over half of these procedures performed on older patients (over 60 years old). Despite this, the treatment of older trauma patients varies widely from their younger counterparts. Whilst diverging demographics and differing management are previously reported, no data is available regarding injury characteristics, comparative delays, cancellations or escalation to other lists.

A glossary for social-to-biological research.

Research has shown that our socially structured experiences elicit a biological response, leading to the observation that numerous biomarkers (objective biological measures that are representative of various biological processes) are socially patterned. This 'social-to-biological' research is of interest to researchers across multiple disciplines and topics and especially to those with an interest in understanding the biological embodiment of the 'social environment'. Combining social and biomarker data is also of relevance to those examining the biological determinants of social behaviours (for example, the relationship between genetics and certain behaviours like smoking).

The gender wage gap across life: Effects of genetic predisposition towards higher educational attainment.

Using two polygenic scores (PGS) for educational attainment in a biomedical study of all those born in a single week in Great Britain in 1958 we show that the genetic predisposition for educational attainment is associated with labour market participation and wages over the life-course for men and women. Those with a higher PGS spend more time in employment and full-time employment and, when in employment, earn higher hourly wages. The employment associations are four times larger for women than for men.

Electronic cigarettes for smoking cessation.

Background: Electronic cigarettes (ECs) are handheld electronic vaping devices that produce an aerosol by heating an e-liquid. People who smoke, healthcare providers, and regulators want to know if ECs can help people quit smoking, and if they are safe to use for this purpose. This is a review update conducted as part of a living systematic review.

Associations between common genetic variants and income provide insights about the socio-economic health gradient.

We conducted a genome-wide association study on income among individuals of European descent (N = 668,288) to investigate the relationship between socio-economic status and health disparities. We identified 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes (the Income Factor). Our polygenic index captures 1-5% of income variance, with only one fourth due to direct genetic effects.

Psychotropic Polypharmacy in Dementia: A Retrospective Analysis for People with Neuropsychiatric Symptoms Referred to an Australian Dementia Support Service.

Background And Objectives: Despite their limited benefits and serious adverse effects, psychotropics remain frequently prescribed for neuropsychiatric symptoms (NPS) of dementia. Psychotropic polypharmacy, the use of two or more concomitant psychotropic medications, is therefore not recommended for people with dementia. The objectives of this study were to investigate the prevalence of psychotropic polypharmacy in Australians living with dementia whose caregivers sought external NPS support from Dementia Support Australia (DSA; the national provider of NPS support) and the association of psychotropic polypharmacy with their demographics and NPS characteristics.

A case study in statistical software development for advanced evidence synthesis: the combined value of analysts and research software engineers.

Background: Since 2015, the Complex Reviews Synthesis Unit (CRSU) has developed a suite of web-based applications (apps) that conduct complex evidence synthesis meta-analyses through point-and-click interfaces. This has been achieved in the R programming language by combining existing R packages that conduct meta-analysis with the shiny web-application package. The CRSU apps have evolved from two short-term student projects into a suite of eight apps that are used for more than 3,000 h per month.

Phylogeny and virulence determinant detection of Fusobacterium necrophorum strains isolated at the UK Anaerobe Reference Unit between 1982 and 2019.

Objectives: The study aims to explore the presence, or absence, of virulence genes and the phylogeny of a multidecade United Kingdom collection of clinical and reference Fusobacterium necrophorum isolates.

Methods: Three hundred and eighty-five F. necrophorum strains (1982-2019) were recovered from storage (-80°C).

Understanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.

Diffusion-weighted imaging (DWI) has been frequently used to examine age-related deterioration of white matter microstructure and its relationship to cognitive decline. However, typical tensor-based analytical approaches are often difficult to interpret due to the challenge of decomposing and (mis)interpreting the impact of crossing fibers within a voxel. We hypothesized that a novel analytical approach capable of resolving fiber-specific changes within each voxel (i.

Rationale and design of the PE-TRACT trial: A multicenter randomized trial to evaluate catheter-directed therapy for the treatment of intermediate-risk pulmonary embolism.

Background: The optimal management of patients with intermediate-risk pulmonary embolism (PE), who have right heart dysfunction (determined by a combination of imaging and cardiac biomarkers) but a normal blood pressure, is uncertain. These patients suffer from reduced functional capacity and a lower quality of life over the long-term, despite use of anticoagulant therapy. Catheter-directed therapy (CDT) is a promising treatment for acute PE that rapidly removes thrombus and potentially improves cardiac dysfunction.

Pulsed beam monitoring for electron FLASH.

Background: Safe implementation and translation of FLASH radiotherapy to the clinic requirehs development of beam monitoring devices capable of high temporal resolution with wide dynamic ranges. Ideal detectors should be able to monitor LINAC pulses, withstand high doses and dose rates, and provide information about the beam output, energy/range, and profile.

Purpose: Two novel detectors have been designed and tested for ultra-high dose-rate (UHDR) monitoring: a multilayer nano-structured 3-layer high-energy-current (HEC3) detector, and a segmented large area, 4-section flat (S4) detector with the goal of exploring their properties for a future combined design.

Transmission of group A Streptococcus in long-term care: An outbreak investigation.

We report 2 outbreaks comprising a cluster of 18 group A Streptococcal infections across 2 nursing facilities. Point prevalence surveillance testing identified 8 of 18 cases, and whole genome sequencing validated transmission pathways. Infection prevention interventions at the facility level comprised symptomatic and asymptomatic carriage-based case finding, transmission-based precautions, and treatment to eradicate colonization.

Simulation studies for methodological research in psychology: A standardized template for planning, preregistration, and reporting.

Simulation studies are widely used for evaluating the performance of statistical methods in psychology. However, the quality of simulation studies can vary widely in terms of their design, execution, and reporting. In order to assess the quality of typical simulation studies in psychology, we reviewed 321 articles published in in 2021 and 2022, among which 100/321 = 31.

Accounting for bias due to outcome data missing not at random: comparison and illustration of two approaches to probabilistic bias analysis: a simulation study.

Background: Bias from data missing not at random (MNAR) is a persistent concern in health-related research. A bias analysis quantitatively assesses how conclusions change under different assumptions about missingness using bias parameters that govern the magnitude and direction of the bias. Probabilistic bias analysis specifies a prior distribution for these parameters, explicitly incorporating available information and uncertainty about their true values.