[Estrogen dependence of mammary gland tumors: the mechanisms of the disorder and the evaluation criteria].

Estrogen-dependent mammary gland tumors, induced in rats by DMBA, were found to show a high content of estradiol receptors. Among hormone-dependent tumors there were ones both with low and high content of the receptors. Loss of estrogen dependence by tumors with a high level of estradiol receptors is due to an impairment of the translocation of estradiol-receptor complexes into nuclei.

[Intranuclear development of the macrogametes of the coccidian, Tyzzeria parvula].

The fine structure of macrogametes of a goose coccidium Tyzzeria parvula has been studied, intranuclear localization of these being discovered. Unlike other coccidia, macrogametes of T. parvula display only one type of wall-forming bodies.

[Impulse propagation in an active unidimensional medium with a trigger-type region of nonuniformity].

Effects are considered which appear during impulse propagation along the active line, some elements of which are converted from the expecting regime to the trigger one. At the set length of the non-uniformity the critical value of the parameter exists, up to which the propagating impulse "takes no notice" of the trigger region. When the parameter values are higher than the critical value, the trigger region starts to generate the propagating impulses.

[Estradiol reception and enzyme induction in mouse mammary gland neoplasms].

Under study was the dependence of mammary gland tumors growth on ovarian hormones level in C3H and DD mice. Tumors arising spontaneously were transplanted to 30--40 mice of the same strain, and tumors of the first passage were studied. The experiments were undertaken on ovariectomized and hormone-treated animals; the latter were given estradiol-benzoate and progesterone injections weekly during a month in the dosage of 5 mcg and 400 mcg per animal, respectively.

[Treatment of reactive stuporous states with L-DOPA].

The paper presents the results of L-dopa use for the treatment of patients with reactive stuporous states. The assumption concerning curability of these patients is based on the similarity of a number of their clinical and biochemical manifestations with an akynetic-rigid form of parkinsonism where L-dopa is very effective. From 25 patients with reactive psychoses 7 demonstrated recovery, 3 patients--significant improvement, 5 patients--improvement and 10 patients--absence of the effect.

[Estradiol reception and induction of DNA-dependent RNA synthesis and adaptive enzymes in the mammary glands of mice].

The content of estradiol receptors in the mammary glands of virgin female mice, and the capacity of this hormone to induce RNA synthesis, hexokinase, pyruvatkinase, and glucose-6-phosphoric dehydrogenase in the glands was studied. H3-estradiol binding to the mammary glands was found to be highly specific: only estradiol, and, to a lesser degree, estron, competed with H2-estradiol for the binding sites, while progesterone and hydrocortisone failed to affect the binding of H3-estradiol. As determined by the method of exchange of the receptor-bound endogenous hormone for the labeled exogenous one, the value of H3-estradiol specific binding was 4.

[Comparison of the blood levels of insulin and growth hormone in healthy adolescents, adolescents with excessive weight and with hereditary loading with regard to diabetes mellitus].

Changes in insulin and growth hormone secretion were studied in 112 children and adolescents (50 healthy ones, 40 with excessive weight, and 22 with heredity aggravated by diabetes mellitus). Three types of these changes were distinguished in healthy adolescents: normoreactive, hyperreactive, and inert. The same type of growth hormone secretion changes corresponded to each type of insulin secretion changes.