Venous thromboembolic events following cytoreductive surgery for lower gastrointestinal neoplasia.

Introduction: Cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) represent a high-risk for venous thromboembolism (VTE) due to malignancy, prolonged surgery and immobility. We investigated the incidence of and risk factors for VTE following CRS/IPC.

Materials And Methods: Data was analysed on 130 CRS/IPC performed over a 6-year period at a single centre, the Western Australian Peritonectomy Service (WAPS), on lower gastrointestinal neoplasia: pseudomyxoma peritoneii (PMP), colorectal cancer (CRC) and appendix cancer (AC).

Xylate effect on the renal toxicological function with diabetes mellitus complicated by endogenous intoxication syndrome of purulent-septic genesis.

Objective: Aim: To study xylate effect on the renal toxin-excreting function with diabetes mellitus (DM) complicated by endogenous intoxication syndrome of purulentseptic genesis.

Patients And Methods: Materials and Methods: The effect of infusions with sorbilact or Ringer's solution in the regimen 3 ml/kg/hour during 3 hours on toxin-excreting function of the kidneys in patients with type 2 DM complicated by EIS is studied.

Results: Results: In the period of the research, xylate increased cleaning blood plasma (extracellular water space) from the total toxicity by 6,0±1,9 ml/min (230±72,3%, Δ р<0,05).

CLINICAL FEATURES OF THE CARIES COURSE OF TEMPORARY TEETH IN CHILDREN.

Objective: The aim: Assess the incidence of caries of temporary teeth in children using the indices drxfm, SIC, ICDAS.

Patients And Methods: Materials and methods: A survey of 255 children 3 and 6 years old was conducted and 2 research groups were formed. We determined the prevalence, intensity of caries by the expanded formula drxfm, SIC-index and ICDAS II 1-6, as well as determined the Green-Vermilion hygienic index.

Design of Beta-2 Microglobulin Adsorbent Protein Nanoparticles.

Beta-2 microglobulin (B2M) is an immune system protein that is found on the surface of all nucleated human cells. B2M is naturally shed from cell surfaces into the plasma, followed by renal excretion. In patients with impaired renal function, B2M will accumulate in organs and tissues leading to significantly reduced life expectancy and quality of life.

Colloidal Nanoribbons: From Infrared to Visible.

Using the cation-exchange method, colloidal PbS nanoribbons are converted completely into CdS nanoribbons. This process expands the emission spectrum of the nanoribbons from infrared to visible. The morphology of nanoribbons remains the same after cation exchange, but the crystal structure changes from rock salt to zincblende.

Elevating Phospholipids Production from Crude Glycerol.

Phospholipids (PLs) are a class of lipids with many proven biological functions. They are commonly used in lipid replacement therapy to enrich cell membranes damaged in chronic neurodegenerative diseases, cancer, or aging processes. Due to their amphipathic nature, PLs have been widely used in food, cosmetic, and pharmaceutical products as natural emulsifiers and components of liposomes.

Are 2 Radiographic Views As Good as 3 Views to Diagnose Ankle Fractures in Children and Adolescents?

Objectives: Ankle radiographs are among the most commonly obtained trauma images in the pediatric population, with the standard 3 views (AP/mortise [M]/lateral [L]) routinely ordered in the emergency department. The purpose of this study was to compare the diagnostic accuracy, sensitivity, and specificity of sets of 2 views (AP/L or M/L) with the standard 3 views.

Methods: One hundred twenty sets of ankle radiographs of skeletally immature patients obtained in the emergency department of a level 1 pediatric trauma center were used.

Tuning the Dimensionality of Excitons in Colloidal Quantum Dot Molecules.

Electrically coupled quantum dots (QDs) can support unique optoelectronic properties arising from the superposition of single-particle excited states. Experimental methods for integrating colloidal QDs within the same nano-object, however, have remained elusive to the rational design. Here, we demonstrate a chemical strategy that allows for the assembling of colloidal QDs into coupled composites, where proximal interactions give rise to unique optoelectronic behavior.

The diverse metabolic heterogeneity of stem cells in a BRCA+/-breast cancer population.

Breast cancers are very heterogeneous tissues constituted by epithelial cancer cells and an abnormal tumor microenvironment - cancer-associated fibroblasts (CAFs), activated adipocytes, mesenchymal stem cells (MSCs), and others. The aim of the study is to cancer cells and their microenvironment, which behave like a complex and heterogeneous metabolic ecosystem, where cancer cells can reprogram their metabolism as a result of interaction with the components of the microenvironment. The study was based on cancer stem cells (CSC) that were isolated from breast tumors by magnetic separation (AutoMACS).

Pediatric biobanks and parents of disabled children associations opinions on establishing children repositories in developing countries.

Pediatric biobanks are an indispensable resource for the research needed to bring advances in personalized medicine into pediatric medical care. It is unclear how or when these advances in medical care may reach children, but it is unlikely that research in adults will be adequate. We conducted the screening for a hypothetic problem in various European and American pediatric biobanks based on online surveys through e-mail distribution based on the Biobank Economic Modeling Tool (BEMT) questionnaire model.

Western Australian Peritonectomy Service: a review of the first 6 years of operation of a low-volume peritonectomy centre.

Background: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal early chemotherapy has gained acceptance as the standard of care for peritoneal surface malignancy over the past decade. This study reports the results of the first 6 years of activity of the Western Australian Peritonectomy Service to compare outcomes of a low-volume centre with world standards.

Methods: An audit of all patients who received CRS ± hyperthermic intraperitoneal early chemotherapy treatment at the Western Australian Peritonectomy Service in its first 6 years of operation was performed and results were compared to the recent world literature.

The condition of volumetric and osmoregulatory function of the kidneys in toxicemia of purulent-septic genesis in patients with diabetes mellitus.

Objective: The aim of the study is to investigate the state of volumetric and osmoregulatory function of the kidneys in diabetes complicated by the syndrome of the endogenous intoxication of purulent-septic genesis.

Patients And Methods: Materials and methods: The study group was consisted of patients with insulin-dependent diabetes mellitus with complicated syndrome of the endogenous intoxication of purulent-septic genesis (CSDI).

Results: Results: The starting indices of volumetric and osmoregulatory function of the kidneys in patients with INCs complicated by the endogenous intoxication of purulent-septic genesis (CEI GHG) syndrome are characterized by the values of the inhibition of the volumorregulatory (by the clearance of sodium by 11%, p <0.

Is it feasible to implement a rapid recovery pathway for adolescent idiopathic scoliosis patients undergoing posterior spinal instrumentation and fusion in a single-payer universal health care system?

Purpose: The purpose of this project was to determine if it is feasible to implement a rapid recovery pathway (RRP) for the surgical treatment of adolescent idiopathic scoliosis (AIS) within a single-payer universal healthcare system while simultaneously decreasing length of stay (LOS) without increasing post-operative complications.

Methods: A retrospective analysis was completed for all patients who underwent posterior spinal fusion for AIS at a tertiary children's hospital in Canada between March 2010 and February 2019, with date of implementation of the RRP being March 1st, 2015. Patient demographic information was collected along with a variety of outcome variables including: LOS, wound complication, infection, 30-day return to the OR, 30-day emergency department visit, and 30-day hospital readmission.

Clinical and immunologic assessment of a complex of therapeutic-preventive measures concerning chronic catarrhal gingivitis in children with comorbid diabetes mellitus.

Objective: The aim of our study is to increase the efficacy of treatment of chronic catarrhal gingivitis in children suffering from type 1 diabetes mellitus by means of improvement of themethods of pharmacological correction on the basis of investigation of clinical-immunologic peculiarities of the disease.

Patients And Methods: Materials and methods: 2 groups of the study were formed. Children received basic insulin therapy.

MICROBIOLOGICAL AND IMMUNOLOGICAL ASSESSMENT OF A COMPLEX OF THERAPEUTIC-PREVENTIVE MEASURES FOR CHRONIC CATARRHAL GINGIVITIS IN CHILDREN WITH DIABETES MELLITUS.

Dysbacteriosis of the oral cavity is known to complicate the course of chronic catarrhal gingivitis resulting from functional disorders of the macroorganism ecosystem, decreased amount of probiotic and increased amount of opportunistic and pathogenic microflora. And natural immune response is activated first in this case. It differentiates pathogens by TLR.

Delayed Photoluminescence in Metal-Conjugated Fluorophores.

Assemblies of metal nanostructures and fluorescent molecules represent a promising platform for the development of biosensing and near-field imaging applications. Typically, the interaction of molecular fluorophores with surface plasmons in metals results in either quenching or enhancement of the dye excitation energy. Here, we demonstrate that fluorescent molecules can also engage in a reversible energy transfer (ET) with proximal metal surfaces, during which quenching of the dye emission via the energy transfer to localized surface plasmons can trigger delayed ET from metal back to the fluorescent molecule.

Colloidal semiconductor nanocrystals in energy transfer reactions.

Excitonic energy transfer is a versatile mechanism by which colloidal semiconductor nanocrystals can interact with a variety of nanoscale species. While this process is analogous to dipole-dipole coupling in molecular systems, the corresponding energy transfer dynamics can deviate from that of molecular assemblies due to manifestations of bulk-like features in semiconductor colloids. In particular, weak exciton binding, small singlet-triplet exciton splitting, and the energy disorder across nanocrystal ensembles can all play distinctive roles in the ensuing energy conversion processes.

International Orthopaedic Multicenter Study in Fracture Care: Coordinating a Large-Scale Multicenter Global Prospective Cohort Study.

Unlabelled: Traditionally, the orthopaedic trauma literature has been dominated by small studies that were largely single-center initiatives. More recently, there has been a paradigm shift toward larger, multicenter studies because the orthopaedic community embraced the concepts of evidence-based medicine and the need for high-quality research to guide clinical practice. The International Orthopaedic Multicenter Study in Fracture Care is a large multicenter international cohort study in musculoskeletal trauma in Africa, Asia, and Latin America.

Challenges and Prospects of Photocatalytic Applications Utilizing Semiconductor Nanocrystals.

Photocatalytic systems based on colloidal semiconductor nanocrystals have gained considerable attention owing to potential benefits that include a visible-range light extinction and a low spatial overlap of photoinduced charges. When coupled to metal catalysts, nanocrystal sensitizers have demonstrated a compelling performance in homogenous photoreduction reactions, including the degradation of organic dyes and hydrogen generation. Going beyond half-cycle reactions, however, the progress in the field of nanocrystal photocatalysis has been rather limited.

Improving the spectral resolution in fluorescence microscopy through shaped-excitation imaging.

The visualization of distinct molecular species represents an important challenge of bio-imaging research. In past decades, the development of multicolor fluorescent (FL) labels has greatly improved our ability to track biological analytes, paving the way for important advances in understanding the cell dynamics. It remains challenging, however, to visualize a large number of different fluorephores simultaneously.

Open versus arthroscopic Latarjet procedures for the treatment of shoulder instability: a systematic review of comparative studies.

Background: The arthroscopic and open Latarjet procedures are both known to successfully treat shoulder instability with high success rates. The objective of this study was to compare the clinical outcomes and positioning of the coracoid graft and screws between the arthroscopic and open Latarjet procedures.

Methods: The electronic databases MEDLINE, EMBASE, and PubMed were searched for relevant studies between database creation and 2018.

Competition of Charge and Energy Transfer Processes in Donor-Acceptor Fluorescence Pairs: Calibrating the Spectroscopic Ruler.

Sensing strategies utilizing Förster resonance energy transfer (FRET) are widely used for probing biological phenomena. FRET sensitivity to the donor-acceptor distance makes it ideal for measuring the concentration of a known analyte or determining the spatial separation between fluorescent labels in a macromolecular assembly. The difficulty lies in extracting the FRET efficiency from the acceptor-induced quenching of the donor emission, which may contain a significant non-FRET contribution.

Thermally activated delayed photoluminescence from pyrenyl-functionalized CdSe quantum dots.

The generation and transfer of triplet excitons across semiconductor nanomaterial-molecular interfaces will play an important role in emerging photonic and optoelectronic technologies, and understanding the rules that govern such phenomena is essential. The ability to cooperatively merge the photophysical properties of semiconductor quantum dots with those of well-understood and inexpensive molecular chromophores is therefore paramount. Here we show that 1-pyrenecarboxylic acid-functionalized CdSe quantum dots undergo thermally activated delayed photoluminescence.

What Is the State of the Evidence in Anterolateral Ligament Research?

The anterolateral ligament (ALL) is a capsular structure of the knee that is the subject of increasing academic interest. This article reviewed recent ALL literature in terms of subject matter and quality. Although current literature focusing on the ALL is small and limited to level 4 and 5 evidence, it is rapidly expanding.