Machine Learning Informed Diagnosis for Congenital Heart Disease in Large Claims Data Source.

Background: With an increasing interest in using large claims databases in medical practice and research, it is a meaningful and essential step to efficiently identify patients with the disease of interest.

Objectives: This study aims to establish a machine learning (ML) approach to identify patients with congenital heart disease (CHD) in large claims databases.

Methods: We harnessed data from the Quebec claims and hospitalization databases from 1983 to 2000.

hART: Deep learning-informed lifespan heart failure risk trajectories.

Background: Heart failure (HF) results in persistent risk and long-term comorbidities. This is particularly true for patients with lifelong HF sequelae of cardiovascular disease such as patients with congenital heart disease (CHD).

Purpose: We developed hART (heart failure Attentive Risk Trajectory), a deep-learning model to predict HF trajectories in CHD patients.

[Further development of prophylactic medical examination of military personnel in Ukraine].

The article presents new principles of carrying out prophylactic medical examination of military personnel: criteria of definition of health groups were proposed, pivotal role of general practitioner in performing of prophylactic medical examination, treatment-and heaIth-improving measures were highlighted. Positive results of introduction of this system of prophylactic medical examination in Kiev garrison enables to recommend it in a wide use to enhance the efficiency of regular medical check-ups in armed forces of Ukraine and other power authorities.

[Smoking among military personnel of young age: bad habit and risk factor].

Anonymous questioning was done among military personnel to study their attitude to healthy way of living and smoking. 80 military persons aged from 18 till 30 participated in the study (40 officers and 40 soldiers). Obtained results showed that 72,5% of soldiers and 42,5% of officers smoked it in connection with compromised heredity may lead to the development of chronic non-infectious disease.

[Ultrasound diagnostics of jaundice].

Ultrasound enables to diagnose jaundice resulted from obturation at some level of bile-ducts in 92,2% of patients with jaundice of the origin by detecting the widening of bile duct system. Ultrasound helps in 95,3% detecting outhepatic obturation of bile ducts, in 72,6% - the cause of the disease. Having this technique as high informative and harmless one can use it to screen patients with jaundice.

[The use of bee and plant products in the treatment and rehabilitation of subjects exposed to the effect of ionizing radiation].

The necessity is substantiated for use of apiphytoproducts in patients with duodenal ulcer who had become victims of Chernobyl accident. Apiphytoproducts were found out to accelerate the natural elimination of cesium radionuclides from the body, to normalize the indices for lipid peroxidation; they can be used on a monotherapy basis or combined with antisecretory or anti-Helicobacter drug preparations.

[The characteristics of the lipid peroxidation status and the activity of the main antioxidative enzymes in patients with duodenal peptic ulcer who took part in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station].

Results are submitted of investigations designed to study processes of lipid peroxidation and activity of chief antioxidant enzymes in those patients with duodenal ulcer who took part in the elimination of the effects of the Chernobyl accident. The above contingent of examinees displayed activation of lipid peroxidation (accumulation of conjugated dienes, keto-dienes, malonic dialdehyde) and decline in the activity of superoxide-dismutase, catalase. The results obtained attest to the need for using antioxidants in a complex therapy of patients with peptic ulcer, who have come to be exposed to ionizing radiation.

[The functional characteristics of the digestive system organs in persons living in a radionuclide-contaminated area].

A comprehensive clinico-instrumental evaluation was performed of 339 individuals residing in areas with high levels of radionuclide contamination, aimed to identify incidence rate for the development of various gastrointestinal tract pathologies. The digestive organs abnormalities were found to occur in 96% of the examinees, and included, for the most part, chronic gastritis, chronic cholecystitis, and ulcero-erosive lesions of gastric and duodenal mucosa. The results obtained warrant long-term follow-up examination of the digestive system status in victims of the Chernobyl accident, employing instrumental methods of investigation along with the institution of curative-and-prophylactic measures.

[The structural-functional changes in the hepatobiliary system of patients with colorectal cancer].

On the grounds of clinical and experimental data on hepatobiliary system obtained by hepatobiliscintigraphy (HBSG) and morphological study of hepatic parenchyma deterioration of hepatocytes and suppression of concentrating abilities of gallbladder were found in 68 patients with colorectal cancer and no clinical and laboratory manifestation. Any antitumor treatment, especially combined with chemotherapy, aggravates the disorders. Surgical intervention provokes transient ciliary dyskinesia.

[The characteristics of the alpha-adrenergic regulation of the cardiovascular system in middle-aged and elderly subjects].

97 practically healthy young adult, elderly and old people were examined to study the age-associated changes in alpha-adrenergic regulation of the cardiovascular system. The values of central and renal hemodynamics, systolic and diastolic cardiac functions, skin and bulbar microcirculation and arterial blood pressure were determined in dynamics after injection of the alpha-stimulator phenylephrine (0.15 mg/kg of body mass intramuscularly) or alpha-blocker prazosin (0.