Publications by authors named "Morotti Elisa"
Aim: The aim was to examine the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), a risk factor for atherosclerotic cardiovascular disease, and its association with glycaemic control metrics in children and adolescents with type 1 diabetes (T1D).
Materials And Methods: We enrolled 244 children and adolescents with T1D (115 girls, mean age: 16.2 ± 3.
Aim: Many adolescents with T1D experience a decline in metabolic control due to erratic eating habits and subpar adherence to treatment regimens. The objective of our retrospective observational study was to assess the effect of the Tandem Control IQ (CIQ) advanced hybrid closed-loop (AHCL) system on a cohort of adolescents with suboptimal glucose control.
Methods: We retrospectively evaluated 20 non-adherent patients with T1D, who were inconsistently using Multiple Daily Injections (MDIs) and flash glucose monitoring and were subsequently started and on CIQ.
Article Synopsis
- The study evaluated how continuous glucose monitoring (CGM) affects quality of life (QoL) for young people with type 1 diabetes (T1D) and their caregivers, focusing on the relationship between CGM satisfaction and QoL.
- Researchers used a cross-sectional approach, analyzing responses from 210 youths with T1D and their parents through specific questionnaires that measure QoL and CGM satisfaction.
- Results indicated that higher satisfaction with CGMs correlated with better QoL across all dimensions, suggesting that enhancing CGM experiences could improve well-being for youths with T1D, regardless of the treatment method used.
Aim: Hypoglycaemic events are linked to microvascular and macrovascular complications in people with type 1 diabetes. We aimed to evaluate the efficacy of glucose sensor [real-time continuous glucose monitoring (RT-CGM)] with predictive alarm (PA) in reducing the time spent below the range (%TBR <70 mg/dl) in a group of adolescents with type 1 diabetes (AwD).
Materials And Methods: This was a crossover, monocentric and randomized study.
Aims: Continuous glucose monitoring (CGM) can improve glucometrics in children with type 1 diabetes (T1D), and its efficacy is positively related to glucose sensor use for at least 60% of the time. We therefore investigated the relationship between CGM satisfaction as assessed by a robust questionnaire and glucose control in pediatric T1D patients.
Methods: This was a cross-sectional study of children and adolescents with T1D using CGM.
Aims: The target of metabolic control (HbA1c < 7% or 53 mmol/mol) recommended by the ADA and ISPAD is attained by 30% of children with Type 1 Diabetes (T1D). Advances in technologies for T1D aim to improve metabolic outcomes and reduce complications. This observational study assesses the long-term outcomes of advanced technologies for treatment of T1D compared to conventional approach started at onset in a group of very young children with T1D.
View Article and Find Full Text PDFAims: Wolfram Syndrome Spectrum Disorder (WFS1-SD), in its "classic" form, is a rare autosomal recessive disease with poor prognosis and wide phenotypic spectrum. Insulin dependent diabetes mellitus (DM), optic atrophy (OA) diabetes insipidus (DI) and sensorineural deafness (D) are the main features of WFS1-SD. Gonadal dysfunction (GD) has been described mainly in adults with variable prevalence and referred to as a minor clinical feature.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on translating and validating the Italian version of the continuous glucose monitoring Satisfaction (CGM-SAT) scale to assess patient satisfaction with diabetes technologies.
- The validation process included thorough methods like forward and backward translation, leading to an excellent completion rate of nearly 100% when administered to 210 patients and 232 parents.
- Results showed moderate to good internal consistency and moderate agreement between parent and young people assessments, indicating the scale effectively measures satisfaction with CGM systems for type 1 diabetes patients in Italy.
An unbiased and replicable profiling of type 1 diabetes (T1D)-specific circulating immunome at disease onset has yet to be identified due to experimental and patient selection limitations. Multicolor flow cytometry was performed on whole blood from a pediatric cohort of 107 patients with new-onset T1D, 85 relatives of T1D patients with 0-1 islet autoantibodies (pre-T1D_LR), 58 patients with celiac disease or autoimmune thyroiditis (CD_THY) and 76 healthy controls (HC). Unsupervised clustering of flow cytometry data, validated by a semi-automated gating strategy, confirmed previous findings showing selective increase of naïve CD4 T cells and plasmacytoid DCs, and revealed a decrease in CD56NK cells in T1D.
View Article and Find Full Text PDFIntroduction: Despite the use of technology, recurrent diabetic ketoacidosis (DKA) prevention remains an unmet need in children and adolescents with T1D and may be accompanied by life-threatening acute complications. We present a rare case of non-occlusive mesenteric ischemia (NOMI) with overt manifestation after DKA resolution and a discussion of recent literature addressing DKA-associated NOMI epidemiology and pathogenesis in children and adolescents.
Case Presentation: A 13-year-old female with previously diagnosed T1D, was admitted at our emergency department with hypovolemic shock, DKA, hyperosmolar state and acute kidney injury (AKI).