Publications by authors named "Morotomi Takashi"

Article Synopsis
  • Recent research indicates that N-acetyl-leucine is significantly lower in the saliva of diabetic patients, prompting this study to explore its presence in human nails as a potential diabetes marker.
  • The study employed a specialized chiral separation method using a C18 column and detected the substance with UPLC-ESI-MS/MS, achieving a high resolution and low limit of detection.
  • Findings reveal that levels of N-acetyl-leucine are significantly reduced in the fingernails of diabetic patients compared to those who are prediabetic and healthy, suggesting its potential use as an early warning biomarker for diabetes.
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Background: Type 2 diabetes patients (DP) have significantly higher plasma levels of valine, leucine, isoleucine and alanine than the controls. Specific amino acids may acutely and chronically regulate insulin secretion from the pancreatic β-cells. We recently identified a metabolic signature of N-acetyl leucine (Ac-Leu) that strongly predicts diabetes development in mice hair.

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We examined processing of change in facial expression. Event-related brain potentials (ERPs) were elicited by successive presentation of two different faces without interval. Smile faces were preceded by either a neutral face of the same person, a smile face of a different person, or a neutral face of a different person, which generated expressional, individual, or both expressional and individual change, respectively.

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It has been reported that attending to a particular location can modulate incoming sensory signals, as reflected by the stimulus-evoked P1 and N1 components of the visual event-related potential (ERPs) in a two-dimensional (2D) display [Attention, Space, and Action: Studies in Cognitive Neuroscience, Oxford University Press, New York, 1999, p. 31]. In contrast, in this study we examined the effect of attention in 3D space using a stereoscopic display.

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