Publications by authors named "Moritz Kielkopf"
Article Synopsis
- Early diagnosis of occult cancer in acute ischemic stroke (AIS) patients might lead to quicker treatment and better outcomes, prompting this study to compare mortality rates based on when cancers were diagnosed.
- The research analyzed data from AIS patients treated between 2015 and 2020, finding that out of 3894 patients, 1.5% were diagnosed with new cancer within a year, with a nearly even split between those diagnosed during hospitalization and after discharge.
- Results indicated no significant difference in long-term mortality between the two groups, suggesting that the timing of cancer diagnosis does not impact survival rates, highlighting the need for larger studies to verify these findings.
Factors impacting D-dimer levels in patients with acute ischemic cerebrovascular events.
J Stroke Cerebrovasc Dis
August 2024
Article Synopsis
- The study aimed to understand how time from symptom onset affects D-dimer levels in patients with acute ischemic stroke (AIS) and transient ischemic attack (TIA), as this knowledge may help identify other thrombotic conditions.
- A total of 2467 AIS patients and 708 TIA patients were analyzed, finding that D-dimer levels were higher in AIS patients compared to TIA patients, with distinct fluctuations in D-dimer levels over time in AIS patients.
- The research concluded that while D-dimer levels in AIS patients change significantly after symptoms begin, TIA patients do not show these time-dependent variations, indicating the need for further studies to better utilize D-dimer as a biomarker in acute stroke cases.
Background: The absence of the susceptibility vessel sign (SVS) in patients treated with mechanical thrombectomy (MT) is associated with poor radiological and clinical outcomes after 3 months. Underlying conditions, such as cancer, are assumed to influence SVS status and could potentially impact the long-term outcome. We aimed to assess SVS status as an independent predictor of long-term outcomes in MT-treated patients.
View Article and Find Full Text PDFBackground And Aim: Paraneoplastic coagulopathy can present as stroke and is associated with specific biomarker changes. Identifying paraneoplastic coagulopathy can help guide secondary prevention in stroke patients, and early cancer detection might improve outcomes. However, unlike ischemic stroke, it remains unclear whether paraneoplastic coagulopathy is associated with transient ischemic attacks (TIA).
View Article and Find Full Text PDFBackground And Aim: Identification of paraneoplastic hypercoagulability in stroke patients helps to guide investigations and prevent stroke recurrence. A previous study demonstrated an association between the absence of the susceptibility vessel sign (SVS) on brain MRI and active cancer in patients treated with mechanical thrombectomy. The present study aimed to confirm this finding and assess an association between the absence of the hyperdense vessel sign (HVS) on head CT and active cancer in all stroke patients.
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- This study looked at the relationship between the absence of a specific MRI sign (susceptibility vessel sign or SVS) and active malignancy in patients with acute ischemic stroke who underwent mechanical thrombectomy.
- The research found that 6.9% of patients had active malignancy, and those without the SVS were significantly more likely to have either active or hidden (occult) malignancy.
- Including SVS status in predictive models improved their performance in identifying malignancy, suggesting it could be a useful marker for detecting related complications in patients with stroke.
Article Synopsis
- A study was conducted to assess the effectiveness of transthoracic (TTE) and transesophageal echocardiography (TEE) in diagnosing high-risk findings in patients who experienced ischemic stroke or transient ischemic attack and had a need for direct oral anticoagulants.
- Out of 424 patients, 292 underwent echocardiography, with TTE revealing 14% and TEE showing 16% of patients with management-relevant health issues, mainly related to coronary artery disease and valvular problems.
- The research found that more severe stroke symptoms, diabetes, and certain biomarkers (like NT-proBNP and troponin levels) were linked to these high-risk findings, highlighting potential indicators for increased stroke
(1) Background: The benefit of acute ischemic stroke (AIS) treatment declines with any time delay until treatment. Hence, factors influencing the time from symptom onset to admission (TTA) are of utmost importance. This study aimed to assess temporal trends and risk factors for delays in TTA.
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