Publications by authors named "Morisseau M"
Article Synopsis
- The study aimed to investigate the relationship between the immune microenvironment and survival outcomes in patients with vulvovaginal melanoma.
- It involved a retrospective analysis of 42 patients, examining tumor-infiltrating lymphocytes and genetic mutations, with significant findings on immune cell presence related to better disease-free survival.
- The researchers concluded that specific types of tumor-infiltrating lymphocytes could indicate disease progression and response to treatments, suggesting the need for further multicenter studies to confirm these results.
Article Synopsis
- * It introduces modern analysis techniques that factor in the timing and recurrence of immune-related AEs (irAEs) in cancer patients treated with immune checkpoint inhibitors, based on the MOTIVATE prospective study findings.
- * Results showed variations in the prevalence and timing of irAEs between melanoma and non-small cell lung cancer (NSCLC) patients, leading to more comprehensive safety assessments that can guide clinical and regulatory decisions.
Article Synopsis
- - The study investigates the effectiveness of high-dose-rate (HDR) brachytherapy as an alternative treatment for localized cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) on the face, focusing on local control, survival rates, and quality of life from 2015 to 2021.
- - Out of 67 patients treated, with a majority having early-stage tumors, the local control rate after three years was 87.05%, and most patients experienced only mild side effects like acute radio-mucositis.
- - Quality of life feedback from patients indicated that 77.8% would recommend HDR brachytherapy, underscoring its effectiveness, tolerance, and positive impact on functional outcomes in
Background: Current guidelines recommend that patients with HER2-low metastatic breast cancer (MBC) receive sequentially two antibody-drug conjugates (ADCs): Sacituzumab Govitecan (SG) and Trastuzumab Deruxtecan (T-DXd), despite a similar payload. However, the effectiveness of one after another is unknown.
Methods: ADC-Low is a multicentre, retrospective study evaluating the efficacy of SG and T-DXd, one after another, with or without intermediary lines of chemotherapy, in patients with HER2-low MBC.
Background: Data suggest an association between positron emission tomography/CT (PET/CT) metabolic metrics and tumor microenvironment in several malignancies, and a potential role of PET/CT to monitor response to immunotherapy.
Objective: To evaluate the correlation between tumor loco-regional extension and tumor-infiltrating lymphocyte infiltration in locally advanced cervical cancer prior to concurrent chemo-radiotherapy.The secondary objective was to assess the association between tumor-infiltrating lymphocytes and PET/CT metabolic metrics.
Article Synopsis
- Researchers wanted to see how well a special swallowing test called VFSS can find leaks in the throat after surgery to remove parts of the throat and voice box.
- They looked at 248 patients who had this surgery and took the swallowing test about a week to two weeks later.
- The test was pretty good at spotting leaks; it helped prevent future problems for many patients who had a positive test result.
Objective: This study evaluated the very long-term results of the Carpentier-Edwards pericardial bioprosthesis in the mitral position, with particular attention to structural valve deterioration based on echocardiographic criteria.
Methods: From 1984 to 2016, 648 patients (mean age 68.8 years; 53.
[The base of the piriform sinus in the surgical treatment of fistula of the 4th endobranchial pouch. Apropos of 8 cases].
Ann Otolaryngol Chir Cervicofac
October 1988
Fistula of the fourth endobrachial pouch, a congenital malformation, can be defined as an abnormal persistence of the canal joining the base of the piriform sinus and the deep surface of the lateral lobe of the thyroid. These fistulae, which have been more clearly understood over the last ten years, still constitute a delicate surgical problem, which is rarely discussed in the literature, based on the detection of their tract at their origin, the piriform sinus. The 8 cases operated at Hôpital Necker since 1981 reveal the variability of their tract, which, according to the authors, warrants an anatomosurgical analysis.
View Article and Find Full Text PDF[Functional radical neck excision. Evaluation of 10 years' experience. Apropos of 434 cases].
Ann Otolaryngol Chir Cervicofac
March 1987
A total of 434 functional évidements of neck were conducted in 313 patients, taking into account all primary localizations. Details of the procedure used are described while emphasizing the need for an évidement tending towards one as complete as a radical operation. Surgery was usually elective (89% of cases) but in 11% considered as essential.
View Article and Find Full Text PDF[Functional surgery of cancer of the hypopharynx. Hemilaryngopharyngectomy, posterior pharyngectomy by bilateral cervical approach].
Ann Otolaryngol Chir Cervicofac
March 1987
The authors report on 48 patients operated by hemi-laryngo-pharyngectomy for spinous carcinoma of the piriform sinus. They try to precise the indications by analysing the factors influencing survival and relapses. They compare surgery to the other methods.
View Article and Find Full Text PDF[Tympanic reconstruction by molded grafts. Value and results. Apropos of experience in 158 cases].
Ann Otolaryngol Chir Cervicofac
March 1987
Use of a moulded aponeurotic graft, shapened and then made rigid by heat and formalin, is a seductive method of tympanic reconstruction because of its simplicity and availability. Indications for and results of the application of this method are analyzed based on experience of 158 cases, with sufficient follow up in 90. The principal indication for use is large perforations, when it is possible to exteriorize the whole canal and almost all the tympanic remains, while doubt exists as to its advantages for treatment of small perforations.
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