[Re-evaluation of immunomodulator treatments for recurrent abortions].

Immunotherapy of spontaneous recurrent abortion is still a matter of controversy. Since 1985, 117 patients were treated in our center. Transfusions of paternal leucocytes (PL) were given to 56 patients and intravenous immunoglobulins (i.

[Immunotherapy of recurrent spontaneous miscarriages (idiopathic abortive disease): preliminary results].

Recurrent spontaneous abortion (greater than or equal to 3 spontaneous miscarriages) represents an entity defined by negative criteria (absence of anatomical, hormonal, autoimmune and chromosomal abnormalities). The immune hypothesis is corroborated by the successes (greater than or equal to 80 %) of specific (paternal leucocytes) or non-specific (intravenous gammaglobulins) immunotherapeutic trials. Studies on the mechanisms of action of those two methods will afford information on the pathogenesis of this condition.