Publications by authors named "Morgan Stephens"
Article Synopsis
- Dysregulated colonic epithelial cell (CEC) proliferation is significant in colorectal cancer, with NF-κB-inducing kinase (NIK) playing a key role in regulating CEC regeneration and differentiation through noncanonical NF-kB signaling.
- Studies using knockout mice showed that the absence of NIK resulted in severe colitis, increased tumor burdens, and an altered microbiome favoring colitis, while the effects varied with the type of cell (CEC vs. myeloid) involved in NIK knockout.
- The research highlights the complex relationship between noncanonical NF-κB signaling and colorectal cancer, suggesting that targeting NIK may offer a strategic approach to managing gastrointestinal inflammation and cancer development.
Predation is a common threat to animal survival. The detection of predators or anti-predator communication signals can be disrupted by anthropogenic noise; however, the mechanism by which responses are affected is unclear. Masking and distraction are the two hypotheses that have emerged as likely explanations for changes in behavior in noise.
View Article and Find Full Text PDFNeurodegenerative disorders can alter neural circuitry long before symptoms appear, but the path from early changes to later pathologies is obscure. In this issue of Neuron, Capizzi et al. (2021) show how early axonal growth defects in Huntington's disease create vulnerability to later degeneration.
View Article and Find Full Text PDFApicocaval juxtaposition (ACJ) is a rare form of viscerocardiac malpositions in association with single-ventricle congenital heart defects. The Fontan surgery is the common palliation, and possible surgical options include ipsilateral, contralateral, and intra-atrial conduits. Concerns include lower hemodynamic performances or risks of conduit compression by the cardiac mass.
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