Publications by authors named "Morgan Paull"
Article Synopsis
- Achondroplasia (ACH) is a common genetic condition leading to disproportionate short stature, caused by mutations in the FGFR3 gene, affecting bone growth.
- A mouse model of ACH was treated with infigratinib, a selective FGFR inhibitor, at lower doses (0.2 and 0.5 mg/kg daily, and 1 mg/kg every 3 days), showing significant improvements in bone growth and skeletal development over 15 days.
- The study confirmed that infigratinib enhanced chondrocyte differentiation and helped alleviate complications like foramen magnum stenosis, suggesting its potential as a safe therapeutic option for children with ACH.
The extensive heterogeneity of biological data poses challenges to analysis and interpretation. Construction of a large-scale mechanistic model of enabled us to integrate and cross-evaluate a massive, heterogeneous dataset based on measurements reported by various groups over decades. We identified inconsistencies with functional consequences across the data, including that the total output of the ribosomes and RNA polymerases described by data are not sufficient for a cell to reproduce measured doubling times, that measured metabolic parameters are neither fully compatible with each other nor with overall growth, and that essential proteins are absent during the cell cycle-and the cell is robust to this absence.
View Article and Find Full Text PDFAn inability to reliably predict quantitative behaviors for novel combinations of genetic elements limits the rational engineering of biological systems. We developed an expression cassette architecture for genetic elements controlling transcription and translation initiation in Escherichia coli: transcription elements encode a common mRNA start, and translation elements use an overlapping genetic motif found in many natural systems. We engineered libraries of constitutive and repressor-regulated promoters along with translation initiation elements following these definitions.
View Article and Find Full Text PDFBackground: Plant biotechnology can be leveraged to produce food, fuel, medicine, and materials. Standardized methods advocated by the synthetic biology community can accelerate the plant design cycle, ultimately making plant engineering more widely accessible to bioengineers who can contribute diverse creative input to the design process.
Results: This paper presents work done largely by undergraduate students participating in the 2010 International Genetically Engineered Machines (iGEM) competition.