Publications by authors named "Morgan McGovern"
Article Synopsis
- - The opioid overdose epidemic is worsening due to the prevalence of fentanyl and its analogues in illicit drugs, prompting the need for better treatment options.
- - This study focuses on the isolation and efficacy of two families of monoclonal antibodies (mAbs) designed to target fentanyl and carfentanil, revealing that humanizing these mAbs reduced their effectiveness.
- - Structural analysis identified a key residue, Tyr36, in murine mAbs that is vital for binding to fentanyl and carfentanil, highlighting the significance of structural insights in engineering mAbs for opioid treatment.
Oncogenic virus infections are estimated to cause ~15% of all cancers. Two prevalent human oncogenic viruses are members of the gammaherpesvirus family: Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV). We use murine herpesvirus 68 (MHV-68), which shares significant homology with KSHV and EBV, as a model system to study gammaherpesvirus lytic replication.
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