Mutations in 406 Are Associated with Low-Level Ethambutol Resistance in Canadian Isolates.

In , molecular predictions of ethambutol resistance rely primarily on the detection of mutations within . However, discordance between 406 mutations and gold standard phenotypic drug sensitivity testing (DST) questions the significance of 406 mutations used in molecular DST. This study tabulates mutations found in Canadian isolates and evaluates the impact of specific mutations on ethambutol resistance.