Incorporating Mitochondrial Gene Expression Changes Within a Testable Mathematical Model for Alzheimer's Disease: Stress Response Modulation Predicts Potential Therapeutic Targets.

Background: Alzheimer's disease is a specific form of dementia characterized by the aggregation of amyloid-β plaques and tau tangles. New research has found that the formation of these aggregates occurs after dysregulation of cellular respiration and the production of radical oxygen species. Proteomic data shows that these changes are also related to unique gene expression patterns.