Publications by authors named "Morgan E Morris"
Article Synopsis
- Mitochondrial membrane potential (ΔΨm) serves as a key indicator of mitochondrial function, and this study aimed to quantify its variability among different human cell types.
- The researchers utilized a dual microscopy method to evaluate the relative and absolute measurements of ΔΨm in unsynchronized cancer cells, cells synchronized in specific phases of the cell cycle, and human fibroblasts.
- Findings revealed that cancer cells exhibit greater heterogeneity in ΔΨm than fibroblasts, with this variability being influenced by internal mitochondrial factors rather than external cell cycle phases or membrane potential differences.
Statins, widely used to treat hypercholesterolemia, inhibit the 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme of cholesterol (Chol) synthesis. Statins have been also reported to slow tumor progression. In cancer cells, ATP is generated both by glycolysis and oxidative phosphorylation.
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