Publications by authors named "Morgan E Blakley"
J Cardiovasc Dev Dis
January 2023
Article Synopsis
- Increased mechanical forces on developing cardiac valves influence the formation of the extracellular matrix (ECM), which is crucial for tissue integrity and cellular signaling.
- The study focused on the pulmonary valve (PV) during a key developmental period from birth to postnatal day 7, analyzing the impact of blood flow on mechanical loading.
- Findings demonstrated that in mice lacking the proteoglycan protease ADAMTS5, the PV showed temporary phenotypic improvement and changes in proteoglycan localization, suggesting that increased blood flow activates ECM proteases that help organize ECM layers essential for cardiac valve maturation.
