Publications by authors named "Morgan C Thomas"
Article Synopsis
- The study discusses the challenges in validating deep generative models for drug discovery, pointing out that retrospective validation is biased since it can't assess newly generated molecules accurately; meanwhile, prospective validation is costly and influenced by human choices.
- Researchers aimed to see if a model (REINVENT) trained on early-stage drug compounds could effectively generate middle or late-stage compounds, using data from both public and in-house projects.
- Results showed that rediscovery rates of middle/late-stage compounds were significantly higher in public projects compared to in-house projects, revealing the limitations of using generative models in real-world drug discovery compared to traditional human-driven methods.
Context: Children and adults with advanced cardiac or respiratory disease may benefit from specialized palliative care (SPC), but there has been little SPC research in this area.
Objectives: To explore pediatric cardiologists' and respirologists' (pediatric clinicians) beliefs about and referral practices to SPC and compare these results to adult cardiologists and respirologists (adult clinicians).
Methods: Pediatric and adult clinicians were sent a survey exploring SPC referral practices and beliefs.
Echocardiography has evolved the first-line imaging for diagnosis and management of pediatric and congenital heart disease all over the world. While it recognized as essential component of pediatric cardiac care delivery, organization of pediatric echocardiography services is very heterogeneous across the world, mainly related to significant differences in material and human resources in heterogeneous health care systems. In this paper, we focus on the role of pediatric sonographers, defined as expert technicians in pediatric echocardiography.
View Article and Find Full Text PDFAims: The pathophysiology of branch pulmonary artery (PA) stenosis after the arterial switch operation, most commonly on the left, is incompletely understood. This study examines factors associated with left PA (LPA) obstruction.
Methods And Results: Cardiac magnetic resonance (CMR) imaging studies performed in patients after arterial switch operation (ASO) were retrospectively analysed.