A Locus on Chromosome 15 Contributes to Acute Ozone-induced Lung Injury in Collaborative Cross Mice.

Ozone (O)-induced respiratory toxicity varies considerably within the human population and across inbred mouse strains, indicative of gene-environment interactions (GxE). Though previous studies have identified several quantitative trait loci (QTL) and candidate genes underlying responses to O exposure, precise mechanisms of susceptibility remain incompletely described. We sought to update our understanding of the genetic architecture of O responsiveness using the Collaborative Cross (CC) recombinant inbred mouse panel.