Publications by authors named "Morgan A O'Brien"
Article Synopsis
- Electrochemotherapy is a promising cancer treatment that not only shrinks tumors but also triggers the immune system to fight cancer.
- Recent studies explored the use of cisplatin alongside electrochemotherapy, finding it effective in reducing tumor growth in various mouse models.
- This approach also led to a decrease in metastatic potential and showed an abscopal effect, where untreated secondary tumors grew less due to the treatment.
Electrochemotherapy is an evolving therapy which has recently been shown to induce an immunogenic form of cell death. It is hypothesized that the immunogenic cell death induced by electrochemotherapy may compliment the responses seen with anti-cancer immunotherapies. We therefore examined the effect of electrochemotherapy in combination with ICOS activation, which promotes the activity of previously activated T cells.
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- The immune system is crucial in fighting cancer, as it can eliminate cancer cells, but it sometimes leaves behind cells that allow tumors to grow unchecked.
- The review discusses various current and emerging treatments that trigger Immunogenic Cell Death (ICD), promoting immune cell activation against tumors.
- Combining these treatments with immune-modulating agents could enhance the immune response and counteract the suppressive tumor environment, potentially transforming anti-cancer therapies.