Publications by authors named "Morgan A Meredith"
Cell Death Dis
October 2022
Article Synopsis
- MLN4924 is a novel small molecule that inhibits NEDD8-activating enzyme (NAE) and is being tested for cancer treatment, but it can also unintentionally enhance cancer cell growth.
- In this study, it was found that MLN4924 increases levels of PD-L1, a protein that helps cancer cells evade the immune system, through specific cellular signaling pathways.
- Combining MLN4924 with MEK inhibitors or anti-PD-L1 antibodies shows promise in reducing tumor growth and counteracting the drug's immunosuppressive effects.
