Publications by authors named "Moretto Stefano"

Purpose: Endoscopic lithotripsy has become widely adopted worldwide and is considered the gold standard for managing upper urinary tract lithiasis. One of its possible complications is post-operative infection. We aimed to review available literature about the role of preoperative antibiotic prophylaxis and its indications.

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Introduction: Extracorporeal shockwave lithotripsy (SWL) is a standard of care for the management of urinary stones up to 2cm. Although it is generally well-tolerated, ESWL can be a painful procedure for some patients. Virtual reality devices (VRDs) have recently proven to be useful in reducing patient-reported pain during SWL.

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Purpose: This analysis aimed to evaluate the clinical relevance of the presurgical systemic inflammation response index (SIRI) in individuals undergoing radical cystectomy (RC).

Methods: In this retrospective study, 228 were categorized into 2 cohorts depending on their SIRI levels using the best cut-off determined by the Youden Index. The association between SIRI and lymph node metastasis (N), advanced pT stage (pT3/pT4), and loco-regional extended state were analyzed at the time of surgery.

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Objective: To evaluate the noise levels of Holmium:YAG (Ho:YAG), Thulium Fiber (TFL), and pulsed Thulium:YAG (p-Tm:YAG) lasers across various settings, focusing on compliance with safety thresholds and potential impact on communication in the operating room (OR).

Materials And Methods: Noise measurements were taken in an empty OR using sound meters placed 1 m from the laser source. Ambient noise, standby, ready, and lasering modes at three settings (0.

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Introduction: We aim to critically assess Microultrasound (mUS) clinical performance in an outpatient setting, focusing on its ability to reduce unnecessary diagnostic procedures, potentially reshape prostate cancer (PCa) diagnostic protocols, and increase the ability to rule out clinically significant (Gleason Score ≥ 3 + 4) PCa (csPCa).

Materials And Methods: Between November 2018 and April 2022, we conducted a prospective study involving men who underwent mUS examination due to clinical symptoms, PSA elevation, or opportunistic early detection of PCa. Experienced urologists performed mUS assessments in an outpatient setting using the prostate risk identification using micro-ultrasound (PRI-MUS) protocol to identify lesions suspicious of csPCa (PRI-MUS score ≥ 3).

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Background: The American Urologic Association (AUA) and the European Association of Urology (EAU) guidelines endorse percutaneous nephrolithotomy (PCNL) for symptomatic stones larger than 20 mm despite significant risks such as bleeding and urosepsis. Robotic pyelolithotomy (RPL) is emerging as an appealing alternative to PCNL, particularly for patients with anatomical variations like pelvic or horseshoe kidneys, malrotation, previous unsuccessful PCNL, and congenital renal anomalies such as ureteropelvic junction obstruction (UPJO).

Methods: A retrospective observational study was conducted involving patients from Miulli Hospital and A.

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Article Synopsis
  • Intravesical recurrence of upper tract urothelial carcinoma after radical nephroureterectomy occurs in 22% to 47%, prompting the need for effective intravesical chemotherapy, which remains underused due to safety and efficacy concerns.
  • A systematic review analyzed 18 studies with 2,483 patients, finding that intravesical chemotherapy significantly lowered the risk of recurrence at 12 months (OR=0.46) and 24 months (OR=0.41) after surgery.
  • The study highlighted a favorable safety profile for intravesical chemotherapy, showing only 9% minor and 0.9% major complications, while the optimal instillation methods require further investigation.
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: Perinephric fluid is commonly identified in patients with renal colic and urolithiasis, especially in cases associated with hydronephrosis. However, its clinical relevance, particularly its impact on treatment decisions and prognosis, is not well established. : This retrospective, single-center study included adult patients who presented to the emergency department (ED) with suspected renal colic between January 2021 and October 2023.

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Background And Objective: The introduction of the Hugo RAS system represents a recent innovation in robotic surgery. The potential benefits and limitations of this system and its integration into clinical practice in urology have yet to be fully delineated. Our objective was to assess surgical, early oncological, and functional outcomes in studies comparing robot-assisted radical prostatectomy (RARP) performed with the new Hugo RAS system and the well-established da Vinci surgical system.

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The Hugo™ Robotic-Assisted Surgery (Hugo™ RAS) system represents a novel advancement in robotic surgical technology. Despite this, there remains a scarcity of data regarding extraperitoneal robot-assisted radical prostatectomy (eRARP) using this system. We conducted a prospective study at Ospedale Regionale "F.

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Article Synopsis
  • The study aimed to compare the effectiveness of high-resolution micro-ultrasound-guided transrectal biopsy (TRBx) versus MRI/conventional transrectal ultrasound-guided transperineal biopsy (TPBx) in detecting clinically significant prostate cancer (csPCa).
  • Researchers analyzed data from 1,423 men who underwent prostate biopsies and found no significant difference in csPCa detection rates between the two methods (45% for TRBx and 51% for TPBx).
  • The study identified key predictors for csPCa detection, including family history, age, positive digital rectal exam results, prostate-specific antigen density, and specific imaging scores, while noting limitations like the retrospective nature of the data analysis.
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Purpose: Previous studies have demonstrated an association between video-gaming experience (VGE) and improved robotics skills. We aimed to evaluate the initial learning curve for the Ily® robotics system (Sterlab, Sophia Antipolis, France) when applied to flexible ureteroscopy (FU) among both medical students and urology surgeons.

Methods: There were two groups, surgeons and students.

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Article Synopsis
  • Multiparametric magnetic resonance imaging (mpMRI) and microultrasound (micro-US) are both effective technologies for detecting significant prostate cancer, but they differ in their performance in biopsy-naïve patients with discordant lesions.
  • In a study of 178 men, micro-US-guided targeted biopsy (micro-US-TBx) showed a higher detection rate for clinically significant prostate cancer (csPCa) compared to mpMRI-guided targeted biopsy (MTBx), with 20% vs. 16% respectively.
  • The combination of mpMRI and micro-US improved detection rates for both clinically significant and clinically insignificant prostate cancer, indicating their synergistic value when used together.
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Purpose: Iatrogenic ureteral strictures (US) after endoscopic treatment for urolithiasis represent a significant healthcare concern. However, high-quality evidence on the risk factors associated with US is currently lacking. We aimed to develop a consensus statement addressing the definition, risk factors, and follow-up management of iatrogenic US after endoscopic treatment for urolithiasis.

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Background: Urolithiasis prevalence varies globally between 1-20%, influenced by regional factors. Robotic pyelolithotomy (RPL) presents an interesting alternative to PCNL, considered the gold standard for symptomatic stones smaller than 20 mm, as it carries a risk of significant complications. However, studies on RPL are limited, especially in anatomically complex cases, where RPL proves to be particularly useful.

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Article Synopsis
  • A systematic review and meta-analysis examined the differences between open radical cystectomy (ORC) and robot-assisted radical cystectomy (RARC) by evaluating data from several randomized controlled trials (RCTs) regarding patient outcomes.
  • The primary focus was on health-related quality of life (QoL) after surgery, with findings showing no significant differences in QoL, complication rates, or oncological outcomes between the two methods at 3 and 6 months post-surgery.
  • RARC had advantages in transfusion rates but required longer operative times and incurred higher costs, making both procedures viable options for treating bladder cancer.
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: to assess surgical, oncological, and functional outcomes of robot-assisted radical prostatectomy (RARP) performed using the novel Hugo™ RAS system. : A systematic review was conducted following the PRISMA guidelines, using PubMed, Web of Science, Scopus, and Embase databases. Eligible papers included studies involving adult males undergoing RARP with the Hugo™ RAS platform, with at least ten patients analyzed.

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Background: Antimicrobial resistance (AMR) remains a significant public health concern, closely linked to antibiotic overuse. During the COVID-19 pandemic, broad-spectrum antibiotics were frequently administered, potentially exacerbating AMR. This study aimed to assess AMR patterns in our urology department before and after the pandemic.

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A 48-year-old man with a medical history of hypertension and no family history of prostate cancer presented with abdominal distension, lower abdominal pain, and lower urinary symptoms. Physical examination revealed a palpable mass in the lower abdomen, and a digital rectal examination detected a firm mass on the anterior side of the rectum. Laboratory tests showed an elevated PSA level (7.

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The artificial urinary sphincter (AUS) implantation is an effective treatment of post-prostatectomy urinary incontinence (PPI). Still, it may result in troublesome complications such as intraoperative urethral lesion and postoperative erosion. Based on the multilayered structure of the tunica albuginea of the corpora cavernosa, we evaluated an alternative transalbugineal surgical technique of AUS cuff placement with the aim to decrease perioperative morbidity while preserving the integrity of the corpora cavernosa.

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We designed a retrospective study to assess the surgical and economic outcomes of robot-assisted laparoscopic pyeloplasty (RALP) compared with open pyeloplasty (OP), including consecutive patients suffering from ureteropelvic junction obstruction and operated on from January 2012 to January 2022 at a single center. Preoperative, intraoperative, and postoperative outcomes, including costs, were comparatively analyzed. The primary outcome was 3-month success, defined as symptom resolution and no obstruction upon diuretic renal scintigraphy.

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Background: The goal of precision medicine in prostate cancer (PCa) is to individualize the treatment according to the patient's germline mutation status. PCa has a very high rate of genetic predisposition compared with other cancers in men, with an estimated rate of cancers ascribable to hereditary factors of 5-15%.

Methods: A systematic search (PubMed, Web of Science, and ClinicalTrials.

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