Effect of standardized Eucalyptus globulus leaf extract on brain oxidative stress and aberrant neurochemistry of fructose-streptozotocin-induced diabetic rats.

The neuro-pharmacological effect of Eucalyptus globulus ethanol leaf extract in fructose-streptozotocin-induced diabetic rats was evaluated in this study. The phytochemical analysis of the extract was carried out using HPLC-DAD. Diabetes was induced in rats with 10% fructose in drinking water and a single intraperitoneal injection of 40 mg/kg streptozotocin (STZ).

Modifying influence of polyphenols on hematotoxicity, cardiotoxicity, and hepatotoxicity induced by liquefied petroleum gas in rats.

Objective: This study was designed to investigate the effects of liquefied petroleum gas (LPG) on hematotoxic, cardiotoxic, and hepatotoxic indices and the modifying influence of selected polyphenols.

Methods: Adult male Wistar rats were exposed to1000 ppm LPG for 10 min at 12-h interval for 30 days with or without cotreatment with 50 mg/kg rutin, quercetin, tannic acid, or gallic acid followed by hematological, biochemical, and histopathological evaluations in animal tissues.

Results: Exposure to LPG induced hematotoxicity, cardiotoxicity, and hepatotoxicity.

Upregulation of PCSK9, rho kinase and cardiac troponin by leaf extract improves fructose-streptozotocin-induced diabetic cardiac dysfunction in rats.

Context: The effect of in diabetic cardiac dysfunction and the possible mechanisms involved have not been explored.

Objective: To evaluate the effect of ethanol leaf extract of (NEE) on the cardiac function of fructose/streptozotocin-induced diabetic rats.

Materials And Methods: Type-2 diabetes was induced in rats with 10% fructose feeding for 14 days and an intraperitoneal administration of 40 mg/kg streptozotocin.