Publications by authors named "Morata L"
Background: We evaluated the microbial burden on gel polished nails (GPN), standard polished nails (SPN) and unpolished nails (UPN) before and after an alcohol-based hand rub (HHAB).
Methods: Three GPN, two SPN and five UPN in both hands were analyzed in 46 health-care workers volunteers. Nail length was maintained ≤2mm during the study.
Introduction: Staphylococcus aureus stands as the predominant etiological agent in postoperative acute prosthetic joint infections (PJI), contributing to 35-50% of reported cases. This study aimed to evaluate the efficacy of dual prophylaxis incorporating cefuroxime and teicoplanin, in combination with nasal decolonization utilizing 70% alcohol, and oral and body lavage with chlorhexidine.
Material And Methods: We conducted a retrospective review of electronic health records regarding primary and revision arthroplasties conducted at our institution from 2020 to 2021.
Article Synopsis
- * The review focuses on the experience of developing a virtual control center for COVID-19 patients in Spain, showcasing how CDSS allowed for real-time monitoring and improved personalized medical care during the pandemic.
- * While CDSS can enhance patient care quality and increase healthcare efficiency, challenges remain, such as the need for training medical professionals to use the systems effectively and maintaining updated software.
Article Synopsis
- The study investigated the impact of Taurolidine-Citrate-Heparin Locking Solution (TCHLS) on reducing catheter-related blood stream infections (CRBSI) in Intensive Care Units (ICUs) at the Hospital Clínic de Barcelona.
- Results showed a decrease in CRBSI from 7.43% in the pre-TCHLS group (2010-2014) to 3.38% in the post-TCHLS group (2015-2018).
- Despite the reduction in infection rates, there were no significant differences in ICU stay duration or mortality rates between the two groups.
Objectives: The prognosis of bone and joint infections (BJI) caused by Gram-negative bacilli (GNB) worsens significantly in the face of fluoroquinolone-resistance. In this setting, scarce pre-clinical and clinical reports suggest that intravenous beta-lactams plus colistin may improve outcome. Our aim was to assess the efficacy and safety of this treatment in a well-characterized prospective cohort.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on a type of bacterium commonly found on the skin of dogs that can lead to infections in pets and zoonotic infections in humans, especially in those with close animal contact.
- Four cases of infections were documented, identified using advanced techniques like MALDI-TOF mass spectrometry and Nanopore sequencing, revealing that three of the bacterial isolates were multidrug resistant, including resistance to methicillin.
- The research highlights the significance of understanding these bacterial infections due to their increasing resistance and the potential for serious complications in humans, particularly those using catheters.
Article Synopsis
- The study analyzed the occurrence of multidrug-resistant (MDR) bacteria in solid cancer patients with bloodstream infections (BSIs) over 25 years, revealing a significant rise in MDR strains, especially ESBL-producing bacteria.
- Among 6,117 BSI episodes, Gram-negative bacilli (GNB) were the most prevalent, and 24.8% of patients received inappropriate empiric antibiotic treatment (IEAT), which correlated with higher mortality rates.
- Risk factors for MDR BSIs included prior antibiotic use, infections occurring during treatment, and specific infection sources, highlighting the need for improved risk assessment and careful antibiotic prescribing to enhance patient outcomes.
Article Synopsis
- Prosthetic joint infections (PJIs) caused by Candida species are serious complications following joint replacement surgeries, with a study reviewing 269 cases between 2010 and 2021 to assess treatment outcomes.
- The majority of infections occurred in older patients (average age 73), primarily in hips and knees, and most cases involved additional bacterial infections; roughly 58% achieved a cure at the two-year follow-up.
- Treatment effectiveness varied significantly depending on the surgical method used, with poorer outcomes linked to the debridement, antibiotics, and implant retention (DAIR) approach and patients older than 70, while infections from Candida parapsilosis tended to have better outcomes.
Introduction: Staphylococcus aureus stands as the predominant etiological agent in postoperative acute prosthetic joint infections (PJI), contributing to 35-50% of reported cases. This study aimed to evaluate the efficacy of dual prophylaxis incorporating cefuroxime and teicoplanin, in combination with nasal decolonization utilizing 70% alcohol, and oral and body lavage with chlorhexidine.
Material And Methods: We conducted a retrospective review of electronic health records regarding primary and revision arthroplasties conducted at our institution from 2020 to 2021.
Article Synopsis
- The study investigates the importance of white blood cell (WBC) count and polymorphonuclear cell (PMN) percentage in synovial fluid for diagnosing acute postoperative peri-prosthetic joint infection (PJI), as current cutoff values for acute PJI are not yet established.
- A systematic review was conducted, analyzing six studies to evaluate the cutoff values, sensitivity, specificity, and overall accuracy of WBC count and PMN percentage in the diagnosis of acute PJI.
- Findings indicate that WBC count is a more reliable diagnostic tool compared to PMN percentage, with a higher diagnostic odds ratio and accuracy, suggesting that focusing on other synovial fluid biomarkers could further enhance diagnosis.
Infection of a native joint, commonly referred to as septic arthritis, is a medical emergency because of the risk of joint destruction and subsequent sequelae. Its diagnosis requires a high level of suspicion. These guidelines for the diagnosis and treatment of septic arthritis in children and adults are intended for use by any physician caring for patients with suspected or confirmed septic arthritis.
View Article and Find Full Text PDFTreatment failure occurs in about 25% of patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. We assessed whether cloxacillin plus fosfomycin achieves better treatment success than cloxacillin alone in hospitalized adults with MSSA bacteremia. We conducted a multicenter, open-label, phase III-IV superiority randomized clinical trial.
View Article and Find Full Text PDFPurpose: We aimed to evaluate the performance of the FilmArray (FA) meningitis/encephalitis (ME) panel. Secondarily, we analyzed the false positive (FP) and false negative (FN) results, as well as the predictive values of the technique, regarding the cerebrospinal fluid (CSF) characteristics.
Methods: FA is a multiplex real-time PCR detecting 14 of the most common ME pathogens in CSF.
Article Synopsis
- Ceftobiprole medocaril (Cefto-M) is a fifth-generation antibiotic approved in Europe for pneumonia treatment, and a study was conducted in Spain to evaluate its use in clinical practice from September 2021 to December 2022.
- The study included 249 patients, mostly older adults with various infections, with respiratory infections being the most common; 67.9% received Cefto-M as empirical treatment, typically as monotherapy for about one week.
- The results showed an 11.2% infection-related mortality, with higher rates in patients with severe conditions like ventilator-associated pneumonia and sepsis, indicating that Cefto-M is generally safe and often used as a last-resort option
Introduction: There are no data on community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections in the context of the chemsex phenomenon. This study aimed to characterize CA-MRSA-related infections in a cohort of people living with HIV (PLWH) who engage in chemsex.
Methods: At the Hospital Clinic of Barcelona, from February 2018 to January 2022, we analyzed CA-MRSA infections diagnosed in a cohort of PLWH who engage in chemsex.
Background: Our aim in this study was to evaluate the clinical and prognostic impact of communicating microbiological information in real time for adult patients with bloodstream infections (BSIs).
Methods: We retrospectively reviewed 6225 clinical episodes of bacteremia in a teaching hospital from January 2013 to December 2019. Bacteremia-associated mortality was compared when blood culture results were relayed to the infectious diseases specialist (IDS) in real time and periods when results were relayed the following morning.
Carriage of multidrug-resistant Gram-negative bacilli: duration and risk factors.
Eur J Clin Microbiol Infect Dis
May 2023
Identification of risk factors influencing the duration of carriage of multidrug-resistant Gram-negative bacilli (MDR-GNB) may be useful for infection control. The aim of this study is to estimate the impact of several factors collected for routine hospital surveillance on the duration of carriage of selected MDR-GNB. From January 2015 to July 2021, patients with at least two clinical/surveillance samples positive for MDR-GNB different from ESBL-producing E.
View Article and Find Full Text PDFBackground: Excellent revisions about antibiotic-loaded bone cement (ALBC) have been recently published. In the present article, we review the principles and limitations of local antibiotic delivery in the context of recent advances in the pathogenesis of prosthetic joint infections (PJI), with particular attention paid to the potential association between ALBC and antimicrobial resistance.
Main Body: Recalcitrance of PJI is related to the ability of pathogens to adapt to particular environments present in bone tissue and protect themselves from host immunity in different ways.
Background: The prevalence of antimicrobial resistance of () in solid organ transplant (SOT) recipients is higher than that of the general population. However, the literature supporting this statement is scarce. Identifying patients at risk of carbapenem resistance (CR) is of great importance, as CR strains more often receive inappropriate empiric antibiotic therapy, which is independently associated with mortality in bloodstream infections (BSIs).
View Article and Find Full Text PDFDalbavancin in clinical practice in Spain: a 2 year retrospective study.
JAC Antimicrob Resist
December 2022
Objectives: Dalbavancin is approved for the treatment of acute bacterial skin and skin-structure infections (ABSSSIs) in adults. Its unique pharmacokinetic properties allow daily dosing to be avoided. The objective was to describe the sociodemographic and clinical characteristics of patients treated with dalbavancin in Spain, and to evaluate its effectiveness and safety in real-world settings.
View Article and Find Full Text PDFObjectives: To analyse the adherence and impact of quality-of-care indicators (QCIs) in the management of Staphylococcus aureus bloodstream infection in a prospective and multicentre cohort.
Methods: Analysis of the prospective, multicentre international S. Aureus Collaboration cohort of S.
Background: There can be unexpectedly positive culture results during elective hip arthroplasty, but the degree to which these are associated with an increased risk of subsequent premature revision is not known.
Question/purpose: Are unexpectedly positive culture results obtained during elective THA associated with an increased likelihood of revision within 5 years of the procedure?
Methods: Between March 2007 and March 2011, the hip unit at our institution performed elective primary THA in 829 patients. We systematically collected three samples in 52% (428 of 829) of the interventions.
Background: There is no reliable microbiological marker to guide the indication and the response to antiviral treatment in patients with coronavirus disease 2019 (COVID-19). We aimed to evaluate the dynamics of subgenomic RNA (sgRNA) in patients with COVID-19 before and after receiving treatment with remdesivir.
Methods: We included consecutive patients admitted for COVID-19 who received remdesivir according to our institutional protocol and accepted to participate in the study.