Description of the fasted serum metabolomic signature of lean and obese cats at maintenance and of obese cats under energy restriction.

This study aimed to investigate the serum metabolomic profile of obese and lean cats as well as obese cats before and after energy restriction for weight loss. Thirty cats, 16 obese (body condition score 8 to 9/9) and 14 lean (body condition score 4 to 5/9), were fed a veterinary weight loss food during a 4-week period of weight maintenance (L-MAINT and O-MAINT). The 16 obese cats were then energy restricted by a 60% energy intake reduction with the same food for a 10-week period (O-RESTRICT).

Are Members of Political Out-Groups More Morally or Physically Disgusting?

Recent research has found that Americans are disgusted by anonymous members of their political out-group. Determining whether the disgust elicited by political out-group members is more physical or moral may contribute to the understating of what enables its elicitation and regulation. Building on research showing the experience of moral disgust involves relatively abstract construal and the experience of physical disgust involves relatively concrete construal, we predicted that disgust experienced toward political out-group members is more moral than physical.

An Assimilative Effect of Stimulus Co-Occurrence on Evaluation Despite Contrasting Relational Information.

The co-occurrence of a neutral stimulus with affective stimuli typically causes the neutral stimulus's evaluation to shift toward the affective stimuli's valence. Does that assimilative effect occur even when one knows the co-occurrence is due to an opposition relation between the stimuli (e.g.

The effects of ambient temperature exposure on feline fecal metabolome.

Introduction: The fecal metabolome provides insight into overall gastrointestinal and microbial health. Methods for fecal sample storage in metabolomics research vary, however, making comparisons within current literature difficult. This study investigated the effect of ambient temperature exposure on microbial-derived metabolites of feline fecal samples.

Evaluative Conditioning: Past, Present, and Future.

Evaluative conditioning (EC) research investigates changes in the evaluation of a stimulus after co-occurrence with an affective stimulus. To explain the motivation behind this research, this review begins with an overview of the history of EC research, followed by a summary of the state of the art with respect to three key questions. First, how should EC procedures be used to influence evaluation? We provide a guide based on evidence concerning the functional properties of EC effects.

Ep300 sequestration to functionally distinct glucocorticoid receptor binding loci underlie rapid gene activation and repression.

The rapid transcriptional response to the transcription factor, glucocorticoid receptor (GR), including gene activation or repression, is mediated by the spatial association of genes with multiple GR binding sites (GBSs) over large genomic distances. However, only a minority of the GBSs have independent GR-mediated activating capacity, and GBSs with independent repressive activity were rarely reported. To understand the positive and negative effects of GR we mapped the regulatory environment of its gene targets.

Emotion Regulation by Psychological Distance and Level of Abstraction: Two Meta-Analyses.

Self-reflection is suggested to attenuate feelings, yet researchers disagree on whether adopting a distant or near perspective, or processing the experience abstractly or concretely, is more effective. Given the relationship between psychological distance and level of abstraction, we suggest the "construal-matching hypothesis": Psychological distance and abstraction differently influence emotion intensity, depending on whether the emotion's appraisal involves low-level or high-level construal. Two meta-analyses tested the effects of psychological distance ( = 230) and level-of-abstraction ( = 98) manipulations on emotional experience.

Attitudes as propositional representations.

Attitudes are mental representations that help to explain why stimuli evoke positive or negative responses. Until recently, attitudes were often thought of as associations in memory. This idea inspired extensive research on evaluative conditioning (EC) and implicit evaluation.

Examining Automatic Stereotyping From a Propositional Perspective: Is Automatic Stereotyping Sensitive to Relational and Validity Information?

Research on automatic stereotyping is dominated by the idea that automatic stereotyping reflects the activation of (group-trait) associations. In two preregistered experiments (total = 391), we tested predictions derived from an alternative perspective that suggests that automatic stereotyping is the result of the activation of propositional representations that, unlike associations, can encode relational information and have truth values. Experiment 1 found that automatic stereotyping is sensitive to the validity of information about pairs of traits and groups.

Incidental Attitude Formation via the Surveillance Task: A Preregistered Replication of the Olson and Fazio (2001) Study.

Evaluative conditioning is one of the most widely studied procedures for establishing and changing attitudes. The surveillance task is a highly cited evaluative-conditioning paradigm and one that is claimed to generate attitudes without awareness. The potential for evaluative-conditioning effects to occur without awareness continues to fuel conceptual, theoretical, and applied developments.

Can (Instructions About) Stimulus Pairings Influence Automatic and Self-Reported Evaluations in the Presence of More Diagnostic Evaluative Information?

Evaluative conditioning (EC) and persuasion are important pathways for shaping evaluations. However, little is known about how these pathways interact. Two preregistered experiments (total = 1,510) examined effects of EC procedures (i.

Testing the judgment-related account for the extinction of evaluative conditioning.

Evaluative conditioning (EC) effects refer to changes in the liking of a neutral (conditioned) stimulus (CS) due to pairing with an affective (unconditioned) stimulus (US). Some research found that EC effects are resistant to presentations of the CS without the US, whereas other studies found evidence for extinction effects. A recent study found extinction of EC only when participants rated the CS before and after the CS-only presentations, but not when CS evaluation was measured once or indirectly with the evaluative priming task.

Bacterial fecal microbiota is only minimally affected by a standardized weight loss plan in obese cats.

Background: Research in humans and mice suggests that obesity influences the abundance and diversity of gastrointestinal (GI) microbiota, and that an "obese microbiome" influences energy metabolism and fat storage in the host. Microbiota membership and composition have been previously assessed in healthy cats. However, research investigating the effects of obesity and weight loss on the cat's fecal microbiota is limited.

The level of construal involved in the elicitation of core versus moral disgust.

Previous research has distinguished between , elicited by revolting physical objects like spoiled food, and , elicited by violations of social norms or moral principles. We suggest that different levels of construal are involved in the elicitation of core disgust and moral disgust. Specifically, we predicted that the elicitation of core disgust involves more concrete than abstract construal, while the elicitation of moral disgust involves more abstract than concrete construal.

The effect of co-occurrence and relational information on speeded evaluation.

After co-occurrence of a neutral conditioned stimulus (CS) with an affective unconditioned stimulus (US), the evaluation of the CS acquires the US valence. This effect disappears when information about the CS-US relation indicates that they are opposite in valence. In that case, people often show a contrastive effect, evaluating the CS with valence opposite of the US.

How actions change liking: The effect of an action's outcome on the evaluation of the action's object.

People like positive objects (e.g., fun activities) and dislike negative objects (e.

Dietary imbalances in a large breed puppy, leading to compression fractures, vitamin D deficiency, and suspected nutritional secondary hyperparathyroidism.

A 6-month-old intact female giant schnauzer dog fed a nutritionally unbalanced homemade diet was evaluated because of a 1-month history of lameness and difficulty walking. Abnormalities identified on ancillary tests, in conjunction with the dog's clinical improvement following diet change, suggested a diagnosis of vitamin D deficiency and nutritional secondary hyperparathyroidism. This report underlines the importance of appropriate feeding management, especially during the vulnerable growth phase.

The effect of storage at ambient temperature on the feline fecal microbiota.

Background: Feline fecal microbiota analyses can potentially be impacted by a variety of factors such as sample preparation, sequencing method and bioinformatics analyses. Another potential influence is changes in the microbiota from storage of samples prior to processing. This study examined the effect of ambient temperature exposure on the feline fecal microbiota composition.

Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc.

CCCTC-binding factor (CTCF) is an organizer of higher-order chromatin structure and regulates gene expression. Genetic studies have implicated mutations in CTCF in intellectual disabilities. However, the role of CTCF-mediated chromatin structure in learning and memory is unclear.

Comparative analysis of T4 DNA ligases and DNA polymerases used in chromosome conformation capture assays.

Three-dimensional (3-D) genome organization in the nuclear space affects various genomic functions. Circular chromosome conformation capture (4C-seq) is a powerful technique that allows researchers to measure long-range chromosomal interactions with a locus of interest across the entire genome. This method relies on enzymatic cleavage of cross-linked chromatin and consecutive ligation to create ligation junctions between physically adjacent loci, followed by PCR amplification of locus-specific associating loci.

The effect of object-valence relations on automatic evaluation.

Two experiments tested the effect of co-occurrence of a target object with affective stimuli on automatic evaluation of the target when the relation between the target and the affective stimuli suggests that they have opposite valence. Participants learned about targets that ended an unpleasant noise or a pleasant music. The valence of such targets is opposite to the valence of the affective stimuli that co-occur with them.