Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP study.

The Stroke Prevention Trial in Sickle Cell Anemia (STOP) was a randomized multicenter controlled trial comparing prophylactic blood transfusion with standard care in sickle cell anemia (SCA) children aged 2 to 16 years selected for high stroke risk by transcranial Doppler (TCD). More than 2000 children were screened with TCD to identify the 130 high-risk children who entered the randomized trial. A total of 5613 TCD studies from 2324 children were evaluated.

Constant holdup times in gas chromatography by programming of column temperature and inlet pressure.

The requirements for attaining constant holdup times in capillary gas chromatography (GC), while linearly programming both column temperature and inlet pressure, are illustrated. A scheme, which is based on a series of responses from isothermal and isobaric conditions, is proposed. The responses from two commonly used GC instruments, one with a mass-selective detector operating at near-vacuum pressure and another with a flame-ionization detector at ambient pressure, are analyzed.

Risk of internal cancers from arsenic in drinking water.

The U.S. Environmental Protection Agency is under a congressional mandate to revise its current standard for arsenic in drinking water.

Craniofacial screening profile: quick screening for congenital malformations.

The correct identification of syndromes and other congenital malformations at an early age is critical for the child, family and care providers. Most specialists who conduct large screenings of young children are not adequately trained to recognize signs and symptoms that should lead to appropriate referral to the clinical geneticist and/or diagnostic team. A systematic approach for recognizing important signs is presented here; a Craniofacial Screening Profile.