A Proposed Approach for the Determination of the Bioequivalence Acceptance Range for Narrow Therapeutic Index Drugs in the European Union.

The current regulatory criterion for bioequivalence of narrow therapeutic index (NTI) drugs in the European Union requires that the 90% confidence interval for the ratio of the population geometric means of the test product compared with the reference for area under the plasma concentration-time curve (AUC), and in certain cases maximum plasma drug concentration (C ), to be included within the tighter acceptance range of 90.00-111.11%.

Young Swimmers' Anthropometrics, Biomechanics, Energetics, and Efficiency as Underlying Performance Factors: A Systematic Narrative Review.

In youth swimming, researchers are interested in understanding how anthropometry and parameters related to swimming technique (biomechanics, energetics, and efficiency) influence the performance. However, there is not any review in the literature that consolidates the body of knowledge of this topic. The objective of this study was to review systematically the current body of work on the influence of determinant factors related to swimming technique (biomechanics, energetics, and efficiency) and anthropometry in the young performance of swimmers.

The use of alternative food sources to improve health and guarantee access and food intake.

To feed and provide Food Security to all people in the world is a big challenge to be achieved with the 2030 Agenda. Undernutrition and obesity are to the opposite of a healthy nutritional status. Both conditions are associated with unbalanced nutrition, absence of food or excess of non-nutritive foods intake.

Dangerous demographics in post-bleach corals reveal boom-bust versus protracted declines.

Thermal-stress events have changed the structure, biodiversity, and functioning of coral reefs. But how these disturbances affect the dynamics of individual coral colonies remains unclear. By tracking the fate of 1069 individual Acropora and massive Porites coral colonies for up to 5 years, spanning three bleaching events, we reveal striking genus-level differences in their demographic response to bleaching (mortality, growth, and recruitment).

Profiling of elite male junior 50 m freestyle sprinters: Understanding the speed-time relationship.

The aim of this study was to (1) analyze and compare the race performance and stability between the fastest and slowest male swimmers during the 50 m freestyle event, and (2) to understand the speed-time relationship in this race. The performances (start, clean swim, and finish) of 86 swimmers (divided into two tiers: best and poorest performances) who competed in the 50 m freestyle event in the 2019 long course LEN European Junior Championships were analyzed. The swimming speed presented a significant difference between the groups (tier #1 vs tier #2) in all sections of the race, in which the start (S0-15 m: p < 0.

Coinfection between SARS-CoV-2 and vector-borne diseases in Luanda, Angola.

Co-epidemics happening simultaneously can generate a burden on healthcare systems. The co-occurrence of SARS-CoV-2 with vector-borne diseases (VBD), such as malaria and dengue in resource-limited settings represents an additional challenge to the healthcare systems. Herein, we assessed the coinfection rate between SARS-CoV-2 and VBD to highlight the need to carry out an accurate diagnosis and promote timely measures for these infections in Luanda, the capital city of Angola.

Discontinuation of bisphosphonates in seniors: a systematic review on health outcomes.

Purpose: Bisphosphonates are used to treat osteoporosis. Despite their benefits on bone mineral density (BMD) and fractures, they have shown adverse effects, sometimes severe, during chronic use. Taken for several years, they achieve long-term bone retention, making deprescribing feasible.

Updated Inventory and Projected Requirements for Specialist Physicians in Geriatrics.

Background: The predicted growth of Canadians aged 65+ and the resultant rise in the demand for specialized geriatric services (SGS) requires physician resource planning. We updated the 2011 Canadian Geriatrics Society physician resource inventory and created projections for 2025 and 2030.

Methods: The number and full-time equivalents (FTEs) of geriatricians and Care of the Elderly (COE) physicians working in SGS were determined.

Optimization of heart failure with reduced ejection fraction prognosis-modifying drugs: A 2021 heart failure expert consensus paper.

Heart failure (HF) with reduced ejection fraction (HFrEF) is associated with high rates of hospitalization and death. It also has a negative impact on patients' functional capacity and quality of life, as well as on healthcare costs. In recent years, new HFrEF prognosis-modifying drugs have emerged, leading to intense debate within the international scientific community toward a paradigm shift for the management of HFrEF.

A 16-week randomized controlled trial of a fish oil and whey protein-derived supplement to improve physical performance in older adults losing autonomy-A pilot study.

Background: Low functional capacity may lead to the loss of independence and institutionalization of older adults. A nutritional intervention within a rehabilitation program may attenuate loss of muscle function in this understudied population.

Objective: This pilot study assessed the feasibility for a larger RCT of a nutritional supplementation in older adults referred to an outpatient assessment and rehabilitation program.

Health-Related Quality of Life in Older Adults With Acute Cardiovascular Disease Undergoing Early Mobilization.

Background: Early mobilization (EM) is safe and feasible in older adults with acute cardiovascular disease (CVD) and may improve posthospitalization patient-centred outcomes. Our objective was to assess posthospitalization health-related quality of life (HRQOL) in older adults with acute CVD undergoing EM.

Methods: Patients aged ≥ 60 years with acute CVD undergoing EM at an academic tertiary centre in Montreal, Quebec were prospectively enrolled from January 2018 to January 2020.

Ozonation of agri-food products for reducing mycotoxin contamination: challenges in grains and particulates processing.

This study evaluated differences in the efficiency of ozonation process to reduce the natural contamination of two mycotoxins, deoxynivalenol (DON) and zearalenone (ZEN), in wheat grains and particulate products. Three different products were used, each one representing a different structure and mycotoxin distribution: (1) wheat grains, with natural mycotoxin distribution inside and among the grains; (2) homemade pellets, with homogenous mycotoxin distribution; (3) ground homemade pellets, with homogeneous mycotoxin distribution, and smaller particles. The ozonation of naturally contaminated wheat grains did not reduce the concentrations of DON and ZEN.

Laboratory capacity assessments in 25 African countries at high risk of yellow fever, August-December 2018.

Introduction: accurate and timely laboratory diagnosis of yellow fever (YF) is critical to the Eliminate Yellow Fever Epidemics (EYE) strategy. Gavi, the Vaccine Alliance recognized the need to support and build capacity in the national and regional laboratories in the Global YF Laboratory Network (GYFLN) as part of this strategy.

Methods: to better understand current capacity, gaps and needs of the GYFLN laboratories in Africa, assessments were carried out in national and regional reference laboratories in the 25 African countries at high risk for YF outbreaks that were eligible for new financial support from Gavi.

Low-volume walking HIIT: Efficient strategy to improve physical capacity and reduce the risk of cardiovascular disease in older women with type 2 diabetes.

Background And Aims: To compare the effect of a low-volume walking high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on risk of cardiovascular diseases and physical capacity in older women with type 2 diabetes (T2D).

Methods: Thirty inactive older women with T2D were randomized into either HIIT (75 min/week) or MICT (150 min/week). Cardiovascular risk profile (lipid profile; waist circumference and fat mass; resting, post-exercise and ambulatory blood pressure [BP]; VO peak; UKPDS score; ABC's) and physical capacity were assessed before and after a 12-week intervention.

Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients.

The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categorized according to: (1) the WHO Clinical Progression Scale-mild, 19 (16.

Assessment of the inter-lap stability and relationship between the race time and start, clean swim, turn and finish variables in elite male junior swimmers' 200 m freestyle.

The aims of this study were to: (1) assess the stability (mean and normative) of the lap performance, and a set of clean swim and turn variables of junior male swimmers in the 200 m freestyle, and; (2) verify the relationship between the start, clean swim, turn, and finish phases in the 200 m freestyle. Seventy-six individual races in the 200 m freestyle at the 2019 long-course LEN European Junior Championships were analysed. Start, clean swim, turn, and finish variables were assessed.

Atherosclerosis: The cost of illness in Portugal.

Introduction And Objectives: Cardiovascular disease is the leading cause of death in Portugal and atherosclerosis is the most common underlying pathophysiological process. The aim of this study was to quantify the economic impact of atherosclerosis in Portugal by estimating disease-related costs.

Methods: Costs were estimated based on a prevalence approach and following a societal perspective.

Quantitative proteomic analysis of marine biofilms formed by filamentous cyanobacterium.

Cyanobacterial molecular biology can identify pathways that affect the adhesion and settlement of biofouling organisms and, consequently, obtain novel antifouling strategies for marine applications. Proteomic analyses can provide an essential understanding of how cyanobacteria adapt to different environmental settings. However, only a few qualitative studies have been performed in some cyanobacterial strains.

Multiplatform metabolomics for an integrative exploration of metabolic syndrome in older men.

Background: Metabolic syndrome (MetS), a cluster of factors associated with risks of developing cardiovascular diseases, is a public health concern because of its growing prevalence. Considering the combination of concomitant components, their development and severity, MetS phenotypes are largely heterogeneous, inducing disparity in diagnosis.

Methods: A case/control study was designed within the NuAge longitudinal cohort on aging.

Green synthesis of carbon nanotubes impregnated with metallic nanoparticles: Characterization and application in glyphosate adsorption.

In the present work, multi-walled carbon nanotubes (MWCNTs) were used as support material for the impregnation of metallic nanoparticles (MNPs) produced by green synthesis. The influences of the plant extracts (pomegranate (Punica Granatum), Eucalyptus, and pecan (Carya illinoinensis, leaves), metal species (copper and iron), metallic concentrations, and type of functionalization (OH and COOH) on the characteristics of the obtained materials were studied. The precursor and impregnated MWCNTs were characterized through X-ray diffraction, Fourier transformed infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, point of charge, N adsorption/desorption isotherms and, X-ray photoelectron spectroscopy.