Publications by authors named "Mor Eytan"
Thrombotic microangiopathy is a severe complication of renal transplantation. Little is known about risk factors, incidence of autoantibodies against complement components, and prognosis. Clinical and laboratory data were retrospectively collected for 13 patients diagnosed with post-transplant thrombotic microangiopathy (PT-TMA) in 2011-2018.
View Article and Find Full Text PDFIntroduction: Since April 2014 the age limitation on candidates listed for organ transplantation in Israel was abolished following the recommendations of a Public Committee. In this research the new policy was examined in light of scarce medical resources and the increased rate of aging in Israel.
Methods: The opinions of twelve medical staff regarding the policy change were analyzed by a qualitative methodology, using semi-structured interviews.
Article Synopsis
- Early post-transplant hyperglycemia (EPTH) is linked to several negative health outcomes for kidney transplant patients, including increased risk of readmissions and the development of post-transplant diabetes mellitus (PTDM).
- A study analyzed the effects of dedicated endocrine care (DEC) compared to routine care (RC) on glycemic control in kidney transplant recipients over an eight-day period.
- Results showed that patients under DEC had better blood glucose management, with lower average blood glucose levels, a higher likelihood of receiving insulin when necessary, and fewer instances of low blood sugar compared to those receiving RC.
Article Synopsis
- - Kidney issues are common in systemic sclerosis (SSc), with about 50% of patients showing altered kidney function, and serious cases (scleroderma renal crisis or SRC) occurring in roughly 20% of patients.
- - SRC is mostly seen in patients with the diffuse cutaneous systemic sclerosis (dcSSc) subtype and those with anti-RNA polymerase III antibodies, but the introduction of ACE inhibitors has significantly reduced related mortality rates from 78% to between 30% and 36%.
- - Despite improvements, many patients still progress to end-stage renal disease (ESRD) requiring treatments like renal replacement therapies, with kidney transplant rates remaining low at 3-8% for SRC patients and 4
Background: Individualizing induction therapy based on immunological risk is crucial for optimizing outcomes in kidney transplantation.
Methods: A retrospective analysis included 157 first live-donor non-sensitized kidney transplant recipients (KTRs). Within this cohort, 96 individuals exhibited low human leukocyte antigen (HLA) matching (5-6 HLA mismatches).
Background: Autosomal dominant polycystic kidney disease (ADPKD)-related end-stage kidney disease (ESKD) often necessitates transplantation. However, the impact of ADPKD on post-transplant outcomes, specifically hemoglobin levels, remains unknown.
Methods: We retrospectively analyzed 513 Kidney Transplant Recipients (KTRs), of whom 81 had ESKD due to ADPKD (20 with pre-transplant native nephrectomy and 61 without).
Living kidney donation has increased significantly, but little is known about the post-donation health-related quality of life (HRQoL) of non-directed donors (NDs) vs. directed donors (DDs). We thus examined the outcomes of 112 living kidney donors (82 NDs, 30 DDs).
View Article and Find Full Text PDFBackground: Since 2014, as part of a priority program within the Israeli Transplant Law, additional points were given to waitlisted candidates with donor cards. We assessed the impact on deceased donor kidney allocation.
Methods: This study enrolled all patients older than 18 y who underwent deceased donor kidney transplantation (January 2016-December 2019).
Article Synopsis
- Organ transplantation became a viable medical field in the mid-20th century, with advancements in surgical techniques, immunology, and drug development improving the outcomes of transplants.
- In Israel, key milestones included the first heart and kidney transplants in the 1960s, the introduction of effective anti-rejection drugs in the 1980s and 1990s, and the establishment of The National Transplant Center in 1994, which streamlined organ allocation and oversight.
- Despite these advances, there remains a significant shortage of organs from deceased donors, highlighting the ongoing challenge of meeting the demand for transplants in Israel.
Background: Bariatric surgery (BS) is the optimal approach for sustained weight loss and may alter donation candidacy in potential donors with obesity. We evaluated the long-term effects of nephrectomy after BS on metabolic profile, including body mass index, serum lipids and diabetes, and kidney function of donors.
Methods: This was a single-center retrospective study.
Introduction: Metrics for posttransplant immune monitoring to prevent over or under immunosuppression in renal transplant recipients (RTRs) are lacking.
Methods: We surveyed 132 RTRs, 38 in the first year posttransplant and 94 >1-year posttransplant, to study the clinical expression of immunosuppressive therapy. A questionnaire administered to these RTRs was divided into physical (Q physical) and mental (Q mental) symptoms.
Data about in-hospital AKI in RTRs is lacking. We conducted a retrospective study of 292 RTRs, with 807 hospital admissions, to reveal predictors and outcomes of AKI during admission. In-hospital AKI developed in 149 patients (51%).
View Article and Find Full Text PDFBackground: The effectiveness of the fourth BNT162b2 vaccination in reducing the rate and severity of coronavirus disease 2019 (COVID-19) caused by the Omicron variant in renal transplant recipients (RTRs) is unknown.
Methods: Interviews were conducted with 447 RTRs regarding the status and timing of the fourth vaccination, prior vaccinations, and preceding COVID-19 infection. RTRs with polymerase chain reaction-confirmed COVID-19 infection from December 1, 2021, to the end of March 2022 were considered to have been infected with the Omicron variant and were interviewed to determine their disease severity.
This Special Issue in renal transplantation covers a variety of clinical and research areas in kidney transplantation [...
View Article and Find Full Text PDFArticle Synopsis
- Obesity among kidney transplant recipients is linked to higher risks of mortality and graft failure, prompting a study comparing outcomes between obese (BMI > 30 kg/m²) and non-obese patients, involving 1403 patients from a single center.
- The study found that obese patients had worse survival rates and higher incidence of graft complications, particularly with deceased donor (DD) transplants, indicating a need for closer consideration of metabolic health in these patients.
- Researchers suggest that weight loss strategies, including the use of GLP-1 inhibitors and possible bariatric surgery, could help improve outcomes for obese patients awaiting kidney transplants.
Background: There are limited data on the impact of bloodstream infections (BSI) following kidney transplantation (KT) on long term patient outcome.
Methods: This was a retrospective parallel-cohort study. We included 123 consecutive KT recipients who were admitted with a first episode of BSI between January 2007 and December, 2016.
An impaired humoral response to full dose of BNT162b2 vaccine was observed in renal transplant recipients (RTR). To reveal predictors for humoral response to third vaccine, patients were stratified to positive (N = 85) and negative (N = 14) response groups based on receptor-binding domain (RBD) IgG ≥1.1 and neutralizing antibodies (NA) ≥ 16 dilution versus RBD IgG <1.
View Article and Find Full Text PDFBackground: Genetic kidney diseases contribute a significant portion of kidney diseases in children and young adults. Nephrogenetics is a rapidly evolving subspecialty; however, in the clinical setting, increased use of genetic testing poses implementation challenges. Consequently, we established a national nephrogenetics clinic to apply a multidisciplinary model.
View Article and Find Full Text PDFUnlabelled: With scarce organ supply, a selection of suitable elderly candidates for transplant is needed, as well as auditing the long-term outcomes after transplant. We conducted an observational cohort study among our patient cohort >60 years old with a long follow up. (1).
View Article and Find Full Text PDFBackground: Trials of the Pfizer-BioNTech BNT162b2 mRNA vaccine showed 95% efficacy in preventing symptomatic disease; however, the trials excluded immunocompromised patients (ICPs). We aim at analyzing antibody response in ICPs.
Methods: A prospective cohort study was conducted at Sheba Medical Center, Israel, between January and April 2020, in 1274 participants who received the vaccine, including 1002 ICPs and 272 immunocompetent healthcare workers (HCWs).
Article Synopsis
- A study was conducted to compare the effectiveness of short (6-10 days) versus prolonged (11-21 days) antibiotic therapy for complicated urinary tract infections (UTIs) in kidney transplant recipients.
- The analysis included 214 patients, revealing that both treatment durations led to similar rates of all-cause mortality, readmissions, and relapsed UTIs within specified time frames.
- Ultimately, the study concluded that there was no significant difference in clinical outcomes between the two antibiotic treatment durations for complicated UTIs in kidney transplant patients.
Background: Hyperuricemia is common after renal transplantation, especially in those receiving calcineurin inhibitors. Little, however, is known about the relationship between uric acid (UA) levels and allograft outcome.
Methods: We conducted a retrospective single-center analysis ( = 368) in order to assess UA blood levels post-transplant association with allograft outcome.
Background: Data about SARS-CoV-2 vaccines efficacy in renal transplant recipients (RTR) are lacking.
Methods: To reveal predictors for humoral response to BNT162b2 vaccine among RTR, patients were divided into positive (N = 42) and negative (N = 78) response groups based on receptor-binding domain (RBD) immunoglobulin G (IgG) ≥1.1 and neutralizing antibodies (NA) ≥16 dilution versus RBD IgG <1.
Article Synopsis
- Whole organ perfusion decellularization aims to create non-immunogenic organs using donor organs from different species or individuals, but repopulating these organs with patient-specific cells is complex.
- The proposed method focuses on replacing only the endothelial cells in the organ while maintaining its overall structure and function, which may streamline the process of making transplantable organs.
- The study successfully demonstrated vascular decellularization in various organs and utilized human-derived endothelial cells to repopulate these vessels, potentially overcoming immunological challenges in transplants.