Publications by authors named "Mor Dahbash"
Objectives: To investigate differences in workplace exposure, demographic and clinical findings in engineered stone (ES) workers from a multinational consortium using the Engineered Stone Silicosis Investigators (ESSI) Global Silicosis Registry.
Methods: With ethics board approval in Israel, Spain, Australia and the USA, ES workers ages 18+ with a physician diagnosis of work-related silicosis were enrolled. Demographic, occupational, radiologic, pulmonary function and silica-related comorbidity data were compared cross-sectionally among countries using analysis of variance, Fisher's exact tests and logistic regression.
Article Synopsis
- The study aimed to assess protein levels involved in coagulation, inflammation, and angiogenesis in the vitreous fluid of patients with different eye conditions.
- It involved collecting vitreous samples from patients undergoing vitrectomy for issues like retinal detachment, comparing them to control groups with macular hole and epiretinal membrane.
- Findings showed that patients with proliferative diabetic retinopathy (PDR) had notably higher levels of several proteins linked to coagulation and inflammation, indicating a strong correlation between these pathways in the context of PDR.
Activated protein C (APC) exerts diverse cell signaling pathways which results in multiple distinct cytoprotective actions. These include anti-apoptotic and anti-inflammatory activities and stabilization of endothelial and epithelial barriers. We studied the ability of APC to inhibit the leakage and the growth of newly formed as well as pre-existing choroidal neovascularization (CNV) and examined the ability of APC to stabilize the Retinal Pigmented Epithelium (RPE).
View Article and Find Full Text PDFChoroidal neovascularization (CNV) is a complication of age-related macular degeneration and a major contributing factor to vision loss. In this paper, we show that in a mouse model of laser-induced CNV, systemic administration of Butyroyloxymethyl-diethyl phosphate (AN7), a histone deacetylase inhibitor (HDACi), significantly reduced CNV area and vascular leakage, as measured by choroidal flatmounts and fluorescein angiography. CNV area reduction by systemic AN7 treatment was similar to that achieved by intravitreal bevacizumab treatment.
View Article and Find Full Text PDFArticle Synopsis
- The study assesses the effectiveness and consistency of a mobile laser indirect ophthalmoscope for inducing choroidal neovascularization (CNV) in mice.
- Researchers used a diode laser and various lenses to standardize parameters like spot size and intensity, and monitored CNV development using multiple evaluation methods.
- Findings indicate the setup is reliable for CNV induction, with significant correlations between laser application and CNV area, and successful inhibition of CNV using VEGF antibodies.
Article Synopsis
- The study examines the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous fluid of patients with various eye conditions to understand their correlation.
- 78 patients were grouped based on their vitreoretinal issues (macular hole/epiretinal membrane, retinal detachment, and diabetic retinopathy), and their IL-6 and TAT levels were measured and compared.
- Findings show significant differences in IL-6 and TAT levels among groups, with diabetes linked to higher IL-6 in retinal detachment cases, indicating that TAT levels may differ due to inflammation and specific eye tissue responses.
Purpose: To examine whether butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, inhibits chemically induced corneal neovascularization (NV) in mice.
Methods: Corneal NV was induced in the right eye of male C57BL mice by application of a mixture of 75% silver nitrate and 25% potassium nitrate to the corneal center. Immediately thereafter, the mice were randomized into 2 groups, receiving an intraperitoneal injection of AN-7 or saline, which served as control.