Publications by authors named "Moosa Raza"
Novel mannich-based derivative of 2-mercaptobenzimidazole (AK7): a new candidate for the treatment of inflammatory arthritis owing to its NF-κB1 inhibitory potential.
Naunyn Schmiedebergs Arch Pharmacol
April 2023
This study investigated the anti-arthritic potential of novel mannich-based derivatives of 2-mercaptobenzimidazole (AK7 and AK9) in rats. The compounds were characterized by NMR and FTIR spectroscopies and their acute anti-inflammatory effects were measured by carrageenan (CRG)-induced paw edema model. The most potent doses of AK7 and AK9 were subsequently evaluated in the complete Freund's adjuvant (CFA)-induced inflammatory arthritis model.
View Article and Find Full Text PDFA halophytic plant, Haloxylon stocksii, is used to treat various inflammatory disorders traditionally. The present study was carried out to investigate the phytochemical parameters, anti-inflammatory, analgesic and cytotoxic potential of the whole plant extracts of H. stocksii.
View Article and Find Full Text PDFFinding a radical cure for diabetes has reached paramount importance in medicine due to the widespread prevalence of the disease. A substantial reduction in insulin-secreting beta cells is evident in diabetes. The failure of cyclin-dependent kinases (CDKs) and cyclins to access the nucleus is responsible for quiescence or senescence in human and rodent beta cells.
View Article and Find Full Text PDFA matrix transdermal patch of bisoprolol fumarate was formulated with different concentrations of Eudragit RS 100 and Methocel E5 with PEG 400 as plasticizer by solvent evaporation technique. Tween 80 was added to the optimized patch to evaluate the effect of permeation enhancer at different concentration through the excised rabbit's skin. The patches were analyzed for weight variation, drug content, swelling index, erosion studies, moisture content, moisture uptake, water vapor transmission rate (WVTR) and water vapor permeability (WVP).
View Article and Find Full Text PDFPistacia khinjuk is one of the fifteen known species of Pistacia belonging to Anacardiaceae family. Keeping in view the possible therapeutic utility of this genus and the lack of literature on this plant, this study involves phytochemical investigation of P. khinjuk and its antioxidant activity.
View Article and Find Full Text PDFArticle Synopsis
- A study assessed the safety of herbal medicines, focusing on the genotoxic and mutagenic effects of two extracts from a medicinal plant using the Ames and MTT assays.
- The aqua-methanolic extract showed significant mutagenicity with a high mutagenic index when tested on specific bacterial strains, while the n-hexane extract was found to be mutagenic but less pronounced.
- Both extracts exhibited cytotoxicity, indicating potential risks for human health, and the study recommends further investigation in animal models to evaluate the safety of the plant.
Article Synopsis
- Many herbal medicines in alternative medicine are not well-researched for safety, potentially putting users at risk.
- This study tested the genotoxic (mutagenicity) and cytotoxic (cell toxicity) effects of various fruit extracts traditionally used in folk medicine using specific bacteria and cell lines.
- Results indicated that both aqueous and ethanolic extracts showed significant mutagenicity and cytotoxicity, suggesting that these fruit extracts may not be safe for use, highlighting the need for more thorough safety evaluations.
Objectives: The aim of the present work was to formulate flurbiprofen (FLB) loaded microspheres of hydroxypropylmethycellulose and ethylcellulose polymers to study the effect of different proportions of the polymer mixture on the release behavior of the drug.
Material And Methods: A series of microspheres were prepared using tween-80 as a surfactant. The prepared microspheres were evaluated for entrapment efficiency (%) and percentage recovery.