Effect of combined bevacizumab and temozolomide treatment on intramedullary spinal cord tumor.

Study Design: C6 glioma cells and an intramedullary spinal cord tumor model were used to evaluate the effect of bevacizumab (Avastin) or temozolomide (TMZ).

Objective: In this study, we hypothesized that treatment with bevacizumab accelerates the therapeutic effect of TMZ on intramedullary gliomas in an animal model.

Summary Of Background Data: Recently therapies for the management of intramedullary malignant gliomas include surgery, chemotherapy, and radiotherapy.

Visual outcome after transsphenoidal surgery in patients with pituitary apoplexy.

Objective: Pituitary apoplexy is one of the most serious life-threatening complications of pituitary adenoma. The purpose of this study is to investigate the visual outcome after early transsphenoidal surgery for the patients with pituitary apoplexy.

Methods: We retrospectively reviewed the 31 patients with pituitary apoplexy who were admitted due to acute visual acuity or field impairment and treated by transsphenoidal surgery.

Robot-assisted transoral odontoidectomy : experiment in new minimally invasive technology, a cadaveric study.

Objective: In the field of spinal surgery, a few laboratory results or clinical cases about robotic spinal surgery have been reported. In vivo trials and development of related surgical instruments for spinal surgery are required before its clinical application. We investigated the use of the da Vinci® Surgical System in spinal surgery at the craniovertebral junction in a human cadaver to demonstrate the efficacy and pitfalls of robotic surgery.

Resolution of isolated unilateral hypoglossal nerve palsy following microvascular decompression of the intracranial vertebral artery.

Isolated hypoglossal nerve paresis due to mechanical compression from a vascular lesion is very rare. We present a case of a 32-year-old man who presented with spontaneous abrupt-onset dysarthria, swallowing difficulty and left-sided tongue atrophy. Brain computed tomographic angiography and magnetic resonance imaging of the brainstem demonstrated an abnormal course of the left vertebral artery compressing the medulla oblongata at the exit zone of the hypoglossal rootlets that was relieved by microvascular decompression of the offending intracranial vertebral artery.

The effect of minocycline on motor neuron recovery and neuropathic pain in a rat model of spinal cord injury.

Objective: Minocycline, a second-generation tetracycline-class antibiotic, has been well established to exert a neuroprotective effect in animal models and neurodegenerative disease through the inhibition of microglia. Here, we investigated the effects of minocycline on motor recovery and neuropathic pain in a rat model of spinal cord injury.

Methods: To simulate spinal cord injury, the rats' spinal cords were hemisected at the 10th thoracic level (T10).

Difference in occurrence of heterotopic ossification according to prosthesis type in the cervical artificial disc replacement.

Study Design: Retrospective study of the difference of heterotopic ossification (HO) occurrence according to 3 different types of prosthesis.

Objective: This study was designed to investigate the difference of HO occurrence according to different type of prosthesis.

Summary Of Background Data: HO is defined as formation of the bone outside the skeletal system.

Cervical spondylolysis: three cases and a review of the current literature.

Study Design: Case report.

Objectives: To describe a rare case of cervical spondylolysis with an adjacent secondary dysplastic change, and to review the current literature regarding cervical spondylolysis.

Summary Of Background Data: Three patients presented with minor trauma history and radiographical C6 level spondylolysis.