Convergent effects of synthetic glucocorticoid dexamethasone and amyloid beta in human olfactory neurosphere-derived cells.

Stressful life events and glucocorticoid (stress) hormones appear to increase the risk of Alzheimer's disease and hasten its progression, but the reasons for this remain unclear. One potential explanation is that when amyloid β (Aβ) pathology is accumulating in the preclinical disease stage, glucocorticoid receptor signalling during stressful events exacerbates cellular dysfunction caused by Aβ. Alternatively, Aβ may disrupt glucocorticoid receptor signalling.

Inclusion Impact of Jack Mackerel Meal in the Red Sea Bream () Feeds Replacing Various Animal Protein Sources for Fish Meal.

This study aims to elucidate manipulation impacts of jack mackerel meal (JMM) in the red sea bream () feeds replacing various animal protein sources for different levels of fish meal (FM) on growth and feed availability. Two-way ANOVA experimental design was applied with three substitution sources: animal protein sources (tuna byproduct meal (TBM), chicken byproduct meal (CBM), and meat meal (MM)) and two FM substitution levels (25% and 50%). The control (Con) diet contained 60% FM.

Identification and comparison of protein composition of biofilms in response to EGCG from and , which showed opposite patterns in biofilm-forming abilities.

Bacterial biofilm is resistant to conventional antibiotic treatments, leading to complications associated with many infection-related human diseases. Epigallocatechin Gallate (EGCG), a phenolic catechin enriched in green tea, is recognized for its anti-bacterial and anti-biofilm activities. In this study, we examined the protein components of the biofilms formed in the absence or presence of EGCG using and which had shown opposing patterns in biofilm formation.

Improving Medical Student Access to Nutrition During the Core Surgery Clerkship.

The rigorous demands of medical education create circumstances that can make it challenging to maintain a healthy diet. Evaluations from students at an urban medical school in the northeast U.S.

Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota.

The gut microbiota is an immune system regulator in the gut-skin axis. Dysfunctional interactions between the gut microbiota and the gut immune system can lead to the development of skin diseases such as atopic dermatitis (AD). Probiotics and postbiotics positively affect the balance of the gut microbiota, immune regulation, protection against pathogens, and barrier integrity.

Super-resolution multi-contrast unbiased eye atlases with deep probabilistic refinement.

Purpose: Eye morphology varies significantly across the population, especially for the orbit and optic nerve. These variations limit the feasibility and robustness of generalizing population-wise features of eye organs to an unbiased spatial reference.

Approach: To tackle these limitations, we propose a process for creating high-resolution unbiased eye atlases.

Role of Arginine and its Metabolism in TGF-β-Induced Activation of Lung Fibroblasts.

Arginine is a conditionally essential amino acid with known roles in protein production, nitric oxide synthesis, biosynthesis of proline and polyamines, and regulation of intracellular signaling pathways. Arginine biosynthesis and catabolism have been linked to TGF-β-induced activation of fibroblasts in the context of pulmonary fibrosis; however, a thorough study on the metabolic and signaling roles of arginine in the process of fibroblast activation has not been conducted. Here, we used metabolic dropouts and labeling strategies to determine how activated fibroblasts utilize arginine.

Viscoelastic particle focusing and separation in a microfluidic channel with a cruciform section.

Considerable attention has been given to elasto-inertial microfluidics, which are widely applied for the focusing, sorting, and separation of particles/cells. In this work, we propose a novel yet simple fabrication process for a microchannel with a cruciform section, where elasto-inertial particle focusing is explored in a viscoelastic fluid. SU-8 master molds for polydimethylsiloxane (PDMS) structures were fabricated via standard photolithography, and then plasma bonding, following self-alignment between two PDMS structures, was performed for the formation of a microchannel with a cruciform section.

Management of Le Fort I Fractures.

Study Design: A retrospective study.

Objective: This retrospective study aims to analyze the results of Le Fort I fracture treatment, with a focus on addressing malocclusion related to the fractures.

Methods: The study included 43 patients diagnosed with Le Fort I fractures who underwent open reduction and internal fixation.

Structure-based virtual screening of natural compounds in preventing skin senescence: The role of epigallocatechin gallate in protein kinase C alpha-specific inhibition against UV-induced photoaging.

This study combines high-throughput screening and virtual molecular docking to identify natural compounds targeting PKC in skin aging. Go 6983, a PKC inhibitor, showed potent suppression of MMP-1 transcription. EGCG was one of the candidates that showed it could significantly lower UVB-induced MMP-1 expression in HaCaT cells, and it had a strong affinity for PKCα.

Development of a rapid LFA test based on direct RT-LAMP for diagnosis of SARS-CoV-2.

Introduction: In response to the rapid spread of the SARS-CoV-2 virus, we developed a rapid molecular approach to diagnose COVID-19 without the need for RNA extraction.

Methods: The study utilized two molecular methods, RT-qPCR and colorimetric RT-LAMP, to diagnose the RdRp and ORF8 genes, respectively, in oro-nasopharyngeal swabs. Due to the high sequence diversity of ORF8 in SARS-CoV and SARS-CoV-2, it has been identified as a suitable target for virus detection.

Patient-reported assessments of chronic cough in clinical trials: accessory or primary endpoints?

Chronic cough is a complex disorder that affects up to 5-10% of the general population. It can be challenging to manage as there are few effective treatments, although several novel antitussives are in clinical development. The endpoints used to assess their efficacy in clinical trials should be optimal; most large clinical trials currently use objective measures as the primary outcome, especially cough frequency.

Effect of Calcium Channel Blockers on Antiplatelet Activity of Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention: Insights from the PTRG-DES Consortium.

Calcium channel blockers (CCBs) are frequently co-administered with clopidogrel in cardiovascular disease. Although an inhibitory drug interaction exists between them, comprehensive large-scale studies for its validation are lacking. We investigated interactions between CCBs and clopidogrel using a large-scale national registry of patients who underwent percutaneous coronary intervention (PCI).

Nurse-Led Clinical Pathway Development for Cardiac Surgery: A Systematic Quality Improvement Approach.

This paper examines the development of a nurse-led clinical pathway at the Royal Columbian Hospital in New Westminster, BC, to enhance care for cardiac surgery patients. The systematic quality improvement project aimed to standardize care and improve outcomes by addressing issues such as prolonged hospital stays, delayed extubation and limited post-operative mobility. By comparing clinical outcomes with benchmarks, the project identified opportunities for improvement, including early ambulation, timely extubation, reduced mortality, readmission rates and length of stay.

Vaccine Logistics Management Information System at Public Health Facilities in Amhara Region, Ethiopia: A Performance Evaluation.

Objectives: This study aimed to evaluate the performance of vaccine logistics management information systems at public health facilities in Amhara Region, Ethiopia.

Methods: An institution-based concurrent explanatory mixed design was used at public health facilities in Amhara Region, Ethiopia. In total, 102 health facilities were selected using the multi-stage, stratified, random-sampling proportionate-to-size method.

Digital therapeutics in Korea: current status, challenges, and future directions - a narrative review.

Digital therapeutics (DTx) are emerging as a transformative innovation in healthcare offering evidence-based digital interventions for the treatment, management, and prevention of various diseases and disorders. In Korea, DTx have gained significant attention as potential solutions to the increasing burden of chronic diseases and mental health conditions. However, the Korean DTx market faces several challenges that hinder its widespread adoption and integration into the national healthcare system.

hERGBoost: A gradient boosting model for quantitative IC prediction of hERG channel blockers.

The human ether-a-go-go-related gene (hERG) potassium channel is pivotal in drug discovery due to its susceptibility to blockage by drug candidate molecules, which can cause severe cardiotoxic effects. Consequently, identifying and excluding potential hERG channel blockers at the earliest stages of drug development is crucial. Most traditional machine learning models predict a molecule's cardiotoxicity or non-cardiotoxicity typically at 10 μM, which doesn't account for compounds with low IC values that are non-toxic at therapeutic levels due to their high effectiveness at lower concentrations.

Exploring the impact of methylation aging on acute myeloid leukemia: Insights from the aging clock.

Acute myeloid leukemia (AML) is more commonly diagnosed in adults. Though there are considerable knowledge about the relationship between adult leukemia and aging, it is rarely studies in children as the occurrence of the disease is rare. Additionally, adult and pediatric AML are known to have different etiology.

Effect of Biological Therapy for Psoriasis on the Development of Psoriatic Arthritis: A Population-Based Cohort Study.

Background: Evidence comparing the impact of various biologics for psoriasis on the progression to psoriatic arthritis (PsA) is limited. We therefore assessed the risk of PsA associated with interleukin (IL)-23 inhibitor, IL-17 inhibitor, or IL-12/23 inhibitor use compared with tumor necrosis factor (TNF) inhibitor use among patients with psoriasis.

Methods: This population-based cohort study used the nationwide claims database from South Korea (2007-2023).

Chromosome-level genome assembly and annotation of the Patagonian toothfish Dissostichus eleginoides.

The Patagonian toothfish (Dissostichus eleginoides) belongs to the Actinopterygii class, and the suborder Notothenioidei, which lives in cold waters in the Southern Hemisphere. We performed assembly and annotation, and we integrated the Illumina short-read sequencing for polishinng, PacBio long-read sequencing for contig-level assembly, and Hi-C sequencing technology to obtain high-quality of chromosome-level genome assembly. The final assembly analysis resulted in a total of 495 scaffolds, a genome size of 844.