Shaping up a Mevalonate Pathway in the - Coculture System for the Production of Sesquiterpenes.

Sesquiterpenoids are one of the most diverse families of natural compounds with various bioactivities and functions. The introduction of an exogenous mevalonate pathway was recognized to be the proficient approach in for sesquiterpene biosynthesis. It is challenging from the coordination of the pathway constituents to forge an active mevalonate pathway, especially the balance of mevalonate generation and consumption by the top and bottom portions of the mevalonate pathway.