Publications by authors named "Moon Sik Oh"
This study investigates a method for programming immune cells using a biomaterial-based system, providing an alternative to traditional cell manipulation techniques. It addresses the limitations of engineered adoptive T cell therapies, such as T cell exhaustion, by introducing a gelatin-hyaluronic acid (GH-GMA) hydrogel system. We characterized tonsil mesenchymal stem cells (TMSCs), lymphatic endothelial cells (T-LECs), stimulated T-CD8 T cells (STCs), and GH-GMA biomaterials.
View Article and Find Full Text PDFBackground/objectives: Tonsil-derived mesenchymal stem cells (TMSCs) are in the limelight in regenerative medicine due to their high proliferation and differentiation potential. It is important to conduct studies to determine the optimal conditions for achieving the maximum yield while maintaining the optimal differentiation capacity of TMSCs.
Methods: This study explores the impact of serial subculture on TMSCs by analyzing gene expression at passages 2, 4, 6, and 8.
Background/objectives: Chronic or intermittent hyperglycemia is associated with the development of diabetic complications. Oxidative stress and inflammation can be altered by hyperglycemia in diverse tissues, including kidneys and eyes, and play a pivotal role in diabetic complications. Our previous studies showed that the water-insoluble 5,7-dihydroxyflvone chrysin effectively combats diabetic damages incurred in diabetic kidneys and retinas.
View Article and Find Full Text PDFArticle Synopsis
- - Osteoporosis is a bone disease mostly affecting postmenopausal women, leading to increased bone loss and higher fracture risk, prompting the exploration of complementary therapies like Cirsium setidens, which contains beneficial polyphenols.
- - The study used OVX (ovariectomized) mice to simulate postmenopausal osteoporosis, administering Cirsium setidens extracts and specific compounds (linarin and acacetin) to evaluate their effects on bone loss over 8 weeks.
- - Results showed that Cirsium setidens extracts and linarin improved bone mineral density and reduced markers associated with bone resorption, while promoting the formation of new trabecular bone and collagen in the OVX mice
Article Synopsis
- Osteoporosis is a significant issue for postmenopausal women, leading to bone loss and a higher fracture risk; complementary therapies, like fish skin collagen, are explored for treatment.
- The study found that collagen from Pangasius hypophthalmus fish skin helps prevent bone loss in ovariectomized mice, showing improvements in bone density and markers of bone health.
- Combining this fish skin collagen with other treatments, such as isoflavone, may enhance bone formation and counteract the negative effects of estrogen loss, suggesting a potential therapeutic synergy for osteoporosis management.
The imbalance between bone resorption and bone formation in favor of resorption results in bone loss and deterioration of bone architecture. Osteoblast differentiation is a sequential event accompanying biogenesis of matrix vesicles and mineralization of collagen matrix with hydroxyapatite crystals. Considerable efforts have been made in developing naturally-occurring plant compounds, preventing bone pathologies, or enhancing bone regeneration.
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