Publications by authors named "Moon June Kim"
In order to elucidate particle size and wall shear effects on the selective binding of nanoparticles to vessel wall, particle binding to the wall of arterial stenosis was computationally analyzed using a transport and reaction model. The attachment rate constant was modeled as a function of shear rate and particle size. The results showed that it had a positive correlation with the shear rate for particles smaller than 600 nm and a negative correlation with the shear rate for particles larger than 800 nm.
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- This study introduces a new approach to improve intraarterial thrombolysis using an ionic polymer-metal composite (IPMC) actuator to enhance the dissolution of blood clots.
- The research involved testing various sizes of IPMC actuators in a vascular phantom model, finding that specific conditions (3 V, 5 Hz, for 5 minutes) significantly increased the effectiveness of thrombolysis compared to standard treatments.
- The study concludes that the developed vibrating polymer actuator probe shows promise for future applications in intravascular thrombolysis and suggests further testing in animal models.
Various nanoparticles have been developed as imaging probes and drug carriers, and their selectivity in binding to target cells determines the efficacy of these functionalized nanoparticles. Since target cells in different arterial segments experience different hemodynamic environments, we study the effects of wall shear rate waveforms on particle binding. We also explore the effects of the kinetic rate constant, which is determined by particle design parameters, on particle binding.
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