Molar uprighting by a nickel-titanium spring based on a setup model.

Molar uprighting is an important adjunctive treatment in orthodontics: repositioning the tilted molar eliminates the potentially pathologic condition and simplifies the ultimate restorative procedure. Although various methods for molar uprighting have been applied successfully, they still have some limitations and disadvantages in tooth movement. This article reports on a new clinical technique for molar uprighting with nickel-titanium springs based on a setup model.

Effects of retraction force and anchorage reinforcement on occlusal force: a model study.

Objectives: The aim of this study was to investigate the effects of retraction force and anchorage reinforcement with orthodontic mini implants on occlusal force.

Materials And Methods: A strain gauge was attached to the palatal surface of the maxillary right first molar on an en masse retraction model.

Results: Occlusal forces were measured from this model, according to different retraction forces that were generated by elastic chain, under varied compressive forces (simulating masticatory forces).

Human Noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma.

Human Noxin (hNoxin, C11Orf82), a homolog of mouse noxin, is highly expressed in colorectal and lung cancer tissues. hNoxin contains a DNA-binding C-domain in RPA1, which mediates DNA metabolic processes, such as DNA replication and DNA repair. Expression of hNoxin is associated with S phase in cancer cells and in normal cells.

OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers.

Previously, we reported that overexpression of Opa (Neisseria gonorrhoeae opacity-associated)-interacting protein 5 (OIP5) caused multi-septa formation and growth defects, both of which are considered cancer-related phenotypes. To evaluate OIP5 as a possible cancer therapeutic target, we examined its expression level in 66 colorectal cancer patients. OIP5 was upregulated about 3.

[Coproduction of qnrB and armA from extended-spectrum beta-lactamase-producing Klebsiella pneumoniae].

Background: Multidrug-resistant Enterobacteriaceae is a worldwide problem. Although various resistance mechanisms have been recognized with increasing frequency, only a few cases of triple resistance of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae have been reported. This study was designed to evaluate the coexistence of qnr (qnrA, qnrB, and qnrS) and 16S rRNA methylase (armA, rmtA, rmtB, and rmtC) in ESBL-producing K.

Transvascular delivery of small interfering RNA to the central nervous system.

A major impediment in the treatment of neurological diseases is the presence of the blood-brain barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain. This 29-amino-acid peptide specifically binds to the acetylcholine receptor expressed by neuronal cells.