Publications by authors named "Mony Thakur"

The role of GTF2I (General Transcription Factor2I) alteration has already been reported in thymic cancer as a valuable biomarker. However, the association of GTF2I mutation with renal cancer for prognosis of immunotherapy is not yet examined. The biologic and oncologic significance of GTF2I in renal cancer was examined at multiomics level such as mutation, copy number alteration, structural variants.

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Article Synopsis
  • Every year, a lot of harmful chemicals like pesticides and synthetic dyes are made and used, which can hurt our soil, air, and water.
  • With the world's population growing, we will need to produce more food, so pesticides will continue to be used a lot in farming.
  • Using special microbes and fungi can help break down these toxic substances in a safer and cheaper way, and this review talks about how these natural solutions work and their challenges.
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In the present era of the COVID-19 pandemic, viral infections remain a major cause of morbidity and mortality worldwide. In this day and age, viral infections are rampant and spreading rapidly. Among the most aggressive viral infections are ebola, AIDS (acquired immunodeficiency syndrome), influenza, and SARS (severe acute respiratory syndrome).

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  • Pseudomonas aeruginosa is a type of bacteria that can cause serious infections, especially in people with weak immune systems.
  • It has special tools called virulence factors that help it survive and stay in the body, making it hard to treat with regular antibiotics.
  • Researchers are looking for new ways to stop this bacteria by using natural substances and designing new molecules to block its harmful actions.
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Streptomyces genera serve as adaptable cell factories for secondary metabolites with various and distinctive chemical structures that are relevant to the pharmaceutical industry. Streptomyces' complex life cycle necessitated a variety of tactics to enhance metabolite production. Identification of metabolic pathways, secondary metabolite clusters, and their controls have all been accomplished using genomic methods.

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AgO, CoO, and ZnO (ACZ) mixed metal quantum dots (QDs) were synthesized by the sol-gel process. Polyaniline (PANI) was prepared by the chemical-oxidative technique. An approach was used for the synthesis of ACZ decorated PANI plastic nanocomposites (NCs).

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Vaccination is the most suitable and persuasive healthcare program for the prohibition of various deadly diseases. However, the higher production cost and purification strategies are out of reach for the developing nations. In this scenario, development of edible vaccine turns out to be the most promising alternative for remodeling the pharmaceutical industry with reduced production and purification costs.

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Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied inducible cell adhesion molecules which is responsible for several immune functions like T cell activation, extravasation, inflammation, etc. The molecule is constitutively expressed over the cell surface and is regulated up / down in response to inflammatory mediators like cellular stress, proinflammatory cytokines, viral infection. These stimuli modulate the expression of ICAM-1 primarily through regulating the ICAM-1 gene transcription.

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