Publications by authors named "Montserrat Rodriguez-Aguirregabiria"
Rapid multiplex molecular syndromic panels (RMMSP) (3 or more pathogens and time-to-results < 6 h) allow simultaneous detection of multiple pathogens and genotypic resistance markers. Their implementation has revolutionized the clinical landscape by significantly enhancing diagnostic accuracy and reducing time-to-results in different critical conditions. The current revision is a comprehensive but not systematic review of the literature.
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- Gram-negative MDR bacteria like Enterobacterales, Acinetobacter baumannii, and Pseudomonas aeruginosa create significant clinical challenges due to complex infections and diagnostics, especially with MBL-producing strains.
- While colistin is effective against these pathogens, its use is limited by resistance and potential kidney damage, making it a last-resort option.
- Newer combinations, including aztreonam with avibactam and cefiderocol, show promising results and are favored for treating MBL-producing infections, with more research needed to refine treatment strategies.
Challenges Facing Two Outbreaks of Carbapenem-Resistant : From Cefiderocol Susceptibility Testing to the Emergence of Cefiderocol-Resistant Mutants.
Antibiotics (Basel)
August 2024
Carbapenem-resistant (CRAB) infections are associated with poor outcomes depending on patient's conditions, clinical severity and type of infection, and treatment is challenging given the limited therapeutic options available. The aim of this study was to describe the clinical and microbiological characteristics of two outbreaks caused by CRAB in an intensive care unit (ICU). In addition, the mechanisms of resistance detected in these strains and the treatment chosen according to the available therapeutic options were analyzed.
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