Male Breast Cancer in Portugal: A Descriptive Analysis of a 20-Year Cohort.

Objective: Male breast cancer (MBC) is a rare malignancy, representing less than 1% of all breast cancer cases. Despite the rising incidence, MBC research remains limited, with most data extrapolated from female breast cancer (FBC). This study evaluated the clinicopathological features, treatment strategies, and survival outcomes of MBC patients in Portugal over two decades.

Pericapsular Nerve Group block in the emergency department for hip fractures: a clinical protocol.

Isolated hip fractures incur significant mortality within 1 year of operative repair. Adequate analgesia is important in maintaining functional status and facilitating recovery. A multi-modal pain management strategy incorporating regional anesthesia may decrease the need for high-dose narcotics and promote faster recovery.

Enhanced Extraction and Separation with HPLC-DAD of Phenolic and Flavonoid Antioxidants from L. Leaves Using Tailored Terpenoid-Based NADES: Comparative Assessment of Antiradical and Antimicrobial Activities.

This study evaluates Natural Deep Eutectic Solvents (NADES) for extracting antioxidant compounds from dried leaves, compared to traditional ethanol extraction. NADES were synthesized using terpenoids (menthol and β-citronellol) and organic acids (lactic and capric acid), characterized by favorable viscosity, density, and pH, ensuring liquid stability at ambient temperature. NADES extraction outperformed ethanol, with NADES 1 yielding the highest bioactive contents: 83.

"Distinct and Separate Issues": Examining US Adults' Attitudes Toward Abortion During COVID-19.

Background: The COVID-19 pandemic reshaped people's healthcare experiences and access to healthcare, including abortion. In response to the COVID-19 outbreak, some policymakers claimed that abortion is a nonessential service and should be restricted. In contrast, other policymakers contended that abortion is time-sensitive essential healthcare, and access to it should be protected.

Epilepsy surgery in patients with Sturge-Weber Syndrome.

Sturge-Weber Syndrome (SWS) is a neurovascular condition caused by a mutation in the GNAQ gene. The most common neurological manifestations of SWS are epilepsy, developmental delay, and stroke-like episodes. Seizures are often the first neurological symptom, and most patients have drug-resistant epilepsy.

Bias Experiences and Burnout: A Multispecialty, Cross-Sectional Survey of Residents and Fellows at a Multisite US Academic Medical Center.

Objective: To explore associations of bias frequency, sources, and types with burnout in a large, multispecialty sample of residents and fellows and to determine whether and how odds of burnout change after adjustment for bias experiences in multiple demographic subgroups.

Methods: Trainees in graduate medical education programs at Mayo Clinic sites were surveyed between October 12, 2020, and November 22, 2020. Survey items measured personal experiences with bias (frequency, sources, types), burnout (2 Maslach Burnout Inventory items), and demographic characteristics (age, gender, race/ethnicity, lesbian-gay-bisexual-transgender-queer-nonbinary-other identification, disability, socioeconomic background, year in school, specialty).

Laser Interstitial Thermal Therapy for the Treatment of Mesial Temporal Lobe Epilepsy in Children.

Objective: Few studies have explored the efficacy of laser interstitial thermal therapy in pediatric epilepsy surgery. This study aims to evaluate seizure-free outcomes in children and adolescents with mesial temporal lobe epilepsy who underwent laser interstitial thermal therapy.

Methods: This was a retrospective cohort study performed at a level 4 epilepsy center.

Validation of the effectiveness of pig farm repopulation protocol following African swine fever outbreaks in the Philippines.

The African swine fever (ASF) epidemic has severely challenged the Philippines' swine industry since 2019. The National African Swine Fever Prevention and Control Program (NASFPCP), launched in 2021, aims to provide guidance for managing ASF through surveillance, monitoring, and swine repopulation. This study evaluates the effectiveness of post-outbreak disinfection protocols and government-mandated measures for repopulation standard.

ST8-t008-SCC IV methicillin-resistant in retail fresh cheese.

This study reports the finding of 3 ST8-t008-SCC IVa (2B) methicillin-resistant (MRSA) strains in fresh cheese purchased within a single market in Costa Rica. In line with the finding of the resistance genes , , (C), and (A) in their genomes, these bacteria showed phenotypic resistance to multiple β-lactams and erythromycin. In addition, they carry genes for acquired resistance to aminoglycosides () and fosfomycin (), and genes for a myriad of virulence factors, including adhesins, hemolysins, and exotoxins.

Maternal oxygenation and fetal-neonatal mortality among patients with COVID-19 requiring advanced respiratory support in ICU: A multicenter prospective cohort study.

Objective: To explore the association of maternal characteristics, oxygenation, and mechanical ventilatory parameters with fetal and neonatal outcomes.

Methods: The present study was a multicenter, binational (Argentina/Colombia), prospective, cohort study, conducted in 21 intensive care units (ICUs) and including pregnant or postpartum patients with COVID-19 pneumonia requiring advanced respiratory support and their fetuses/neonates. Advanced respiratory support was defined as high-flow nasal cannula (HFNC), non-invasive ventilation (NIV) or invasive mechanical ventilation (IMV).

[Estimates of mortality from external causes in Brazil, 2010-2019: methodology for redistribution of garbage causes].

Insufficient quality of the underlying cause of death in the Brazilian Mortality Information System (SIM), acronym in Portuguese underlists violence and it is necessary to redistribute garbage causes (GC) into valid causes in public health prevention. This study estimated mortality from external causes using the GC redistribution method (GBD-Brazil) and compared it with SIM and estimated data from the GBD-IHME study from 2010 to 2019 in Brazil and its states. The GBD-Brazil GC redistribution algorithm applies previous steps of the GBD-IHME with modifications, using two criteria: proportion of target causes (valid) or reclassification of investigated causes.

On the Complex Flow Dynamics of Shear Thickening Fluids Entry Flows.

Due to their nature, using shear thickening fluids (STFs) in engineering applications has sparked an interest in developing energy-dissipating systems, such as damping devices or shock absorbers. The Rheinforce technology allows the design of customized energy dissipative composites by embedding microfluidic channels filled with STFs in a scaffold material. One of the reasons for using microfluidic channels is that their shape can be numerically optimized to control pressure drop (also known as rectifiers); thus, by controlling the pressure drop, it is possible to control the energy dissipated by the viscous effect.

Case Report: Trauma group therapy with karate-do for war-traumatized children and adolescents.

Background: From the viewpoint of health and education, traumatized children and adolescents who have fled from war and conflict zones to Switzerland represent a high-risk group, as they suffer from psychiatric symptoms to an above-average extent and on several levels: somatic, psychological, psychosomatic, and psychosocial.

Objectives: The complexity and severity of these problems overwhelm the existing school structures in many cases: There is a clear need for psychotherapeutic interventions here that goes beyond purely verbal conversational therapy and provides an holistic concept.

Methods: We propose the following novel approach: "Trauma group therapy with karate-do for war-traumatized children and adolescents" which integrates and applies the evidence-based methods of integrative Budo-Therapy, trauma-focused Cognitive Behavioral Therapy (TF-CBT), Narrative Exposure Therapy (NET) and Integrative Gestalt Therapy according to Dr.

Ketogenic diet therapy for epilepsy: Clinical pearls.

This manuscript provides practical insights, tips, and lessons particularly valuable for early-career healthcare professionals new to using ketogenic diet therapy (KDT) in clinical practice. The review aims to be accessible, emphasizing actionable knowledge that can be directly applied in a clinical setting. The KDT for epilepsy includes not only the classic KDT but also the modified Atkins diet, the medium-chain triglyceride ketogenic diet, and the low glycemic index treatment.

The Transition to Adulthood: A Qualitative Study of Autism Spectrum Disorder From Military and Veteran Parents and Military-Dependent Young Adults.

Introduction: Given the unique experiences of military service members and their families, military-dependent young adults (18-25 years old) with autism spectrum disorder (ASD) and their military or veteran families experience unique barriers to accessing quality mental health care during the transition to adulthood. In fact, developing services to address ASD challenges for military families is a burgeoning area of interest for the department of defense. However, there is a limited knowledge on the specific needs of military families as the young adult's transition outside of high school and lose supports.

Sense of Belonging Among Medical Students, Residents, and Fellows: Associations With Burnout, Recruitment Retention, and Learning Environment.

Purpose: This study examines sense of belonging (belongingness) in a large population of medical students, residents, and fellows and associations with learner burnout, organizational recruitment retention indicators, and potentially modifiable learning environment factors.

Method: All medical students, residents, and fellows at Mayo Clinic sites were surveyed between October and November 2020 with items measuring sense of belonging in 3 contexts (school or program, organization, surrounding community), burnout (2 Maslach Burnout Inventory items), recruitment retention indicators (likelihood of recommending the organization and accepting a job offer), potentially modifiable learning environment factors, and demographics (age, gender, race and ethnicity, LGBTQ+ identification, disability, socioeconomic background).

Results: Of 2,257 learners surveyed, 1,261 (56%) responded.

The long odyssey for the DEE-CDKL5 diagnosis: A call for action.

Objectives: This study aims to determine the current state of CDD diagnosis and epilepsy treatment in an upper-middle-income country.

Methods: Forty-seven families of the Brazilian CDD Association were invited to participate in an online survey to gather information about the diagnosis and treatment of epilepsy.

Results: Forty-three families (91.

Pregnancy in girls under 14 years old: Spatial analysis in Brazil, 2011-2021.

The objective was to analyze the spatial distribution of pregnancy in children under 14 years and six months by Brazilian region and municipality and sociodemographic and health characteristics of pregnant women and live births. Ecological study analyzing the Live Birth Information System (SINASC) from 2011 to 2021 in three age groups (< 14 years and six months, 15-19 years, and 20 years and above) by demographic and birth variables. We applied the Global and Local Moran.

Advancing toward precision migraine treatment: Predicting responses to preventive medications with machine learning models based on patient and migraine features.

Objective: To develop machine learning models using patient and migraine features that can predict treatment responses to commonly used migraine preventive medications.

Background: Currently, there is no accurate way to predict response to migraine preventive medications, and the standard trial-and-error approach is inefficient.

Methods: In this cohort study, we analyzed data from the Mayo Clinic Headache database prospectively collected from 2001 to December 2023.

Molecular Docking Studies of Ortho-Substituted Phenols to Tyrosinase Helps Discern If a Molecule Can Be an Enzyme Substrate.

Phenolic compounds with a position ortho to the free phenolic hydroxyl group occupied can be tyrosinase substrates. However, ortho-substituted compounds are usually described as inhibitors. The mechanism of action of tyrosinase on monophenols is complex, and if they are ortho-substituted, it is more complicated.

Immobilization of Horseradish Peroxidase onto Montmorillonite/Glucosamine-Chitosan Composite for Electrochemical Biosensing of Polyphenols.

Glucosamine-chitosan synthesized by the Maillard reaction was combined with montmorillonite to obtain a nanohybrid composite to immobilize horseradish peroxidase. The material combines the advantageous properties of clay with those of the chitosan derivative; has improved water solubility and reduced molecular weight and viscosity; involves an eco-friendly synthesis; and exhibits ion exchange capacity, good adhesiveness, and a large specific surface area for enzyme adsorption. The physicochemical characteristics of the composite were analyzed by infrared spectroscopy and X-ray diffraction to determine clay-polycation interactions.

Is Stroke risk analysis (SRA) a reliable method for predicting atrial fibrillation? A systematic review.

Introduction: Atrial fibrillation is responsible for a considerable number of cases of cardioembolism, accounting for 17% to 30% of the etiologies of all strokes. The software known as Stroke Risk Analysis (SRA) detects patients at high risk of paroxysmal atrial fibrillation by analyzing a continuous electrocardiogram recorded over different periods of time.

Objectives: This article aims to carry out a systematic review investigating the effectiveness of the SRA method in predicting the risk of stroke patients having paroxysmal atrial fibrillation as the cause of the event.

EEG in focal and generalized epilepsies: Pearls and perils.

Correctly diagnosing and classifying seizures and epilepsies is vital to ensure a tailored approach to patients with epilepsy. The ILAE seizure classification consists of two main groups: focal and generalized. Establishing if a seizure is focal or generalized is essential to classify the epilepsy type and the epilepsy syndrome, providing more personalized treatment and counseling about prognosis.