Publications by authors named "Montawatt Amnueypol"
Article Synopsis
- Brugada syndrome (BrS) is a hereditary cardiac disorder linked to sudden death in young adults, particularly prevalent in Southeast Asia, with certain genetic variants associated with the condition.
- Researchers conducted genome sequencing on individuals with BrS and matched controls in Thailand to find rare noncoding variants that are more common in BrS patients.
- A specific rare variant was identified that disrupts a transcription factor binding site, causing reduced gene expression and reduced sodium current in heart cells, contributing to the high prevalence of BrS in the region and identifying at-risk individuals.
Background: Direct oral anticoagulants (DOACs) are commonly used to prevent stroke and systemic embolism in patients with atrial fibrillation (AF). However, studies into their effectiveness and safety in the Thai population have so far been limited.
Objectives: To study the effectiveness and safety of warfarin and DOACs among Thai AF patients.
Article Synopsis
- Mutations in SCN5A are rare in Thai patients with Brugada syndrome (BrS), prompting a study to identify both common and rare genetic variants linked to the condition in Thailand.
- A genome-wide association study (GWAS) involving 154 BrS cases and 432 controls revealed significant associations with two loci: one near SCN5A/SCN10A and another near HEY2, suggesting these regions are important in understanding BrS genetics.
- The study also found a higher prevalence of rare and low-frequency coding variants in SCN5A among BrS patients, indicating a diverse genetic background for the disorder in the Thai population, similar to findings in European and Japanese groups.
Background: We conducted a multicenter study to evaluate mapping and ablation of ventricular fibrillation (VF) substrates or VF triggers in early repolarization syndromes (ERS) or J-wave syndrome (JWS).
Methods: We studied 52 patients with ERS (4 women; median age, 35 years) with recurrent VF episodes. Body surface electrocardiographic imaging and endocardial and epicardial electroanatomical mapping of both ventricles were performed during sinus rhythm and VF for localization of triggers, substrates, and drivers.
Background: Angiotensin Receptor Blockades (ARB) is becoming a first line drug for essential Hypertension for many types of patient. Losartan is the prototype of ARB due to its vast clinical trials. Home Blood pressure monitoring can provide accurate evaluation of certain drug effect on blood pressure with small number of patient samples.
View Article and Find Full Text PDFBackground: The benefits of catheter ablation for elderly patients with atrial fibrillation (AF) with respect to mortality and stroke reductions remain unclear.
Objective: The purpose of this study was to evaluate the safety and efficacy, including long-term outcomes, of catheter ablation for maintaining normal sinus rhythm (NSR) in elderly patients with AF.
Methods: We evaluated 587 elderly patients (age ≥75 years) with AF.
Background: Systemic thromboembolism and bleeding remain the two most common and serious complications of catheter ablation of atrial fibrillation. A variety of periprocedure anticoagulation strategies have been proposed to mitigate these risks. Although operators are now routinely administering dabigatran for anticoagulation in this setting, its relative safety and effectiveness compared to warfarin are unknown.
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