Publications by authors named "Montano Durso"
Article Synopsis
- MicroRNAs (miRNAs) are important regulatory elements in mammals that interact with transcribed ultraconserved regions (T-UCRs), affecting gene expression processes.
- Evidence shows that manipulating one component of the miRNA-T-UCR network in bladder cancer cells can influence the expression of other components, indicating a tightly interconnected system.
- The interaction between miRNAs, T-UCRs, and the polycomb protein YY1 reveals a new layer of gene expression regulation that has implications for understanding cancer biology.
Ultraconserved regions (UCRs) have been shown to originate non-coding RNA transcripts (T-UCRs) that have different expression profiles and play functional roles in the pathophysiology of multiple cancers. The relevance of these functions to the pathogenesis of bladder cancer (BlCa) is speculative. To elucidate this relevance, we first used genome-wide profiling to evaluate the expression of T-UCRs in BlCa tissues.
View Article and Find Full Text PDFMost GastroIntestinal Stromal Tumors (GISTs) are characterized by KIT gene overexpression, which in turn is regulated by levels of microRNA 221 and microRNA 222. GISTs can also be distinguished by their miRNAs expression profile in which miRNAs 221/222 result reduced in comparison with GI normal tissues. In this paper, to restore normal miRNAs levels and to improve the silencing performances of miRNAs 221/222, new miRNA mimics in which guide strands are modified by Phosphorothioate (PS) and/or 2'-O-methyl RNA (2'-OMe) inside and outside the seed region, were synthesized and tested in GIST48 cells.
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