[Chi-square test of homogeneity in clinical studies: A tool for analyzing differences between treatments].

This article explores the application of the chi-squared test of homogeneity in the context of clinical studies, using a previous study on the efficacy of two analgesics for treating headache as an example. The sample included 215 patients, whose responses to treatment were assessed and recorded across four pain intensity categories. The test allowed for the identification of significant differences between the treatments evaluated, proving to be a valuable statistical tool for comparing groups in clinical research.

Implementation of Distance-Based Simulation Training Programs for Healthcare Professionals: Breaking Barriers During COVID-19 Pandemic.

The sudden rise of critically ill patients secondary to the SARS-CoV-2 pandemic has triggered a surge in healthcare response. This project's goal was to provide essential cognitive and technical skills to healthcare professionals returning to the workforce or reassigned to critical care clinical duties during the COVID-19 pandemic. The plan included the implementation of 4 distance-based simulation training programs, with asynchronous personalized feedback.

C-doped anatase TiO: Adsorption kinetics and photocatalytic degradation of methylene blue and phenol, and correlations with DFT estimations.

This work shows an easy and eco-friendly methodology to obtain almost pristine anatase phase of TiO by using furfural, a biomass-derived molecule, as a bio-template. The photocatalytic activity was studied following the degradation of methylene blue and phenol under artificial solar irradiation. Results were compared against those obtained on a commercial pristine anatase TiO.

Electroencephalographic Biomarkers for Treatment Response Prediction in Major Depressive Illness: A Meta-Analysis.

Objective: Reducing unsuccessful treatment trials could improve depression treatment. Quantitative EEG (QEEG) may predict treatment response and is being commercially marketed for this purpose. The authors sought to quantify the reliability of QEEG for response prediction in depressive illness and to identify methodological limitations of the available evidence.

MoodNetwork: An Innovative Approach to Patient-centered Research.

Introduction: Research has often been viewed as a passive process by which participants enroll in studies developed by researchers. It is becoming clearer that to understand the nuances of mood episodes and how to prevent them, we need to conduct large clinical trials that have the power to investigate moderators and mediators, or catalysts and mechanisms of change. MoodNetwork, the first online, patient-centered research community for individuals with mood disorders, aims to change the way that traditional research has been conducted by involving patients, their caregivers, and advocates in the process of research.

[Thromboelastography and classical coagulation tests in the preoperative period of liver transplantation].

Background: Compared to standard coagulation essays (SCE), such as international normalized ratio (INR), prothrombin activated partial thromboplastin time (aPTT), or platelet count, thromboelastograhy (TEG) offers precise and real-time information about hemostasis. TEG tests both platelet function and coagulation by assaying several parameters of clot formation dynamically in whole blood.

Aim: To evaluate hemostasis in cirrhotic patients undergoing liver transplantation and determine the positive and negative predictive values of SCE for alterations of TEG.

Design of Ag/ and Pt/TiO-SiO nanomaterials for the photocatalytic degradation of phenol under solar irradiation.

The design of hybrid mesoporous TiO-SiO (TS1) materials decorated with Ag and Pt nanoparticles was performed. The photocatalytic degradation of phenol under artificial solar irradiation was studied and the activity and selectivity of the intermediate products were verified. TiO-SiO was prepared by sol-gel method while Ag- and Pt-based photocatalysts (TS1-Ag and TS1-Pt) were prepared by photodeposition of the noble metals on TS1.

Bipolar mixed features - Results from the comparative effectiveness for bipolar disorder (Bipolar CHOICE) study.

Background: DSM-5 changed the criteria from DSM-IV for mixed features in mood disorder episodes to include non-overlapping symptoms of depression and hypomania/mania. It is unknown if, by changing these criteria, the same group would qualify for mixed features. We assessed how those meeting DSM-5 criteria for mixed features compare to those meeting DSM-IV criteria.

Photochemical reactivity of apical oxygen in KSr(2)Nb(5)O(15) materials for environmental remediation under UV irradiation.

The photocatalytic activity of a series of novel KSrNbO materials was studied using the photooxidation of methylene blue as model reaction. The influence of the calcination time upon the crystalline structure and photoactivity was verified. Characterization was performed by XRD, SEM, FTIR, UV-Vis/DR, Helium picnometry, and N and CO adsorption-desorption isotherms.

Poor quality of life and functioning in bipolar disorder.

Background: This study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder.

Methods: Adult participants (N = 482) with bipolar I or II disorder were enrolled in a comparative effectiveness study across eleven study sites and completed baseline measures of medical and psychiatric history, current mood, quality of life, and functioning. Participants with at least mildly depressive or manic/hypomanic symptomatic severity were randomized to receive lithium or quetiapine in addition to adjunctive personalized treatment for 6 months.

Cognitive Remediation and Bias Modification Strategies in Mood and Anxiety Disorders.

Purpose Of Review: Cognitive impairments and biases, which are prevalent in patients with mood and anxiety disorders, can affect quality of life and functioning. Traditional treatments are only insufficiently addressing these impairments and biases. We review the cognitive impairments and biases present in these disorders as well as treatments targeting these domains.

L-Methylfolate For Bipolar I depressive episodes: An open trial proof-of-concept registry.

Background: L-methylfolate is a compelling candidate to treat bipolar I major depressive episodes. While approved as an adjunct for unipolar major depressive disorder, no studies have been done to assess the tolerability, safety, and efficacy of L-methylfolate for bipolar depression. As a first step, we developed a registry of bipolar patients treated with L-methylfolate to examine tolerability and outcomes.

Fab(nimotuzumab)-HYNIC-99mTc: Antibody Fragmentation for Molecular Imaging Agents.

Finally, fast blood clearance nimotuzumab is a humanized monoclonal antibody that recognise, with high specific affinity, the epidermal growth factor receptor (EGF-R) which play an important role in the growth process associated with many solid tumors. In this work, the whole antibody was digested with papain in order to generate a Fab fragment, derivatized with NHS-HYNIC-Tfa and radiolabel with technetium-99m (99mTc) as a potential agent of molecular imaging of cancer. Both, whole and fragment radiolabels were in-vivo and in-vitro characterized.

Assessment of central venous catheterization in a simulated model using a motion-tracking device: an experimental validation study.

Background: Central venous catheterization (CVC) is a basic requirement for many medical specialties. Simulated training in CVC may allow the acquisition of this competency but few reports have established a valid methodology for learning and acquiring procedural skills for CVC. This study aims to validate the use of a tracking motion device, the imperial college surgical assessment device (ICSAD), by comparing it with validated global rating scales (GRS) to measure CVC performance in a simulated torso.

Influence of anatase and rutile phase in TiO2 upon the photocatalytic degradation of methylene blue under solar irradiation in presence of activated carbon.

The influence of activated carbon (AC) on the photocatalytic activity of different crystalline TiO2 phases was verified in the photocatalytic degradation of methylene blue under UV and solar irradiation. The results showed a volcano trend with a maximum photoactivity for the crystalline phase ratio of anatase:rutile equal to 80:20 both under UV or solar irradiation. By contrast, in presence of AC the photocatalytic activity of the binary materials of TiO2/AC followed an exponential trend, increasing as a function of the increase in anatase proportion in the TiO2 framework.

Influence of activated carbon upon the photocatalytic degradation of methylene blue under UV-vis irradiation.

Photodegradation of methylene blue (MB) was studied on TiO2 in the presence of activated carbon (AC) prepared from the sawdust of a soft wood by physical activation under CO2 flow, by pyrolysis under N2 flow, and by chemical activation with ZnCl2 and H3PO4 under N2 flow. MB photodegradation was performed under UV and UV-visible irradiation to verify the scaling-up of the present TiO2-AC binary materials. It was verified that oxygenated surface groups on carbon were intrinsically photoactive, and a synergy effect between both solids has been estimated from the first-order apparent rate constants in the photodegradation of MB.

[Simulation in medical education: a synopsis].

Clinical simulation is defined as a technique (not a technology) to replace or amplify real experiences with guided experiences that evoke or replicate substantial aspects of the real world in a fully interactive fashion. Over the past few years, there has been a significant growth in its use, both as a learning tool and as an assessment for accreditation. Example of this is the fact that simulation is an integral part of medical education curricula abroad.

[Bringing clinical simulation into an Anesthesia residency training program in a university hospital. Participants' acceptability assessment].

Introduction: Clinical simulation is currently an integral part of the curriculum of the Anesthesiology residency programs in other countries. We aimed to describe and evaluate the insertion of simulation in an anesthesia residency training program.

Methods: Activities feasible to be used for training in a simulated environment were classified into 2 modules: workshops for technical skills conducted with first year residents, and high fidelity simulation scenarios performed with second and third year residents.

[Impact on the implementation of patient controlled epidural analgesia for pain management during labor. A survey in a university hospital in Chile].

Objective: Analgesia for labor is a legal obligation in Chile. In our institution we implemented patient controlled analgesia for pain relief during labor. We describe the perception of the several professionals involved in the medical care of patients in labor in terms of effectiveness, usefulness, satisfaction, and safety.

Yttrium-90 -- current status, expected availability and applications of a high beta energy emitter.

Yttrium-90 ((90)Y, T(1/2) 64.14 h) is a key example of a high beta energy-emitting radionuclide which is available from the strontium-90 ((90)Sr)/(90)Y radionuclide generator system. Clinical uses of (90)Y-labeled radiopharmaceutical agents have been pursued for many years and many applications have proven to be clinical effective.

[Evaluation of competencies for tracheal intubation among medical students].

Background: Chilean medical schools curricula are focused on the acquisition of competencies. Tracheal intubation is considered a terminal competence.

Aim: To evaluate the competencies related to airway management including tracheal intubation in undergraduate medical students.