Four-month-old with severe PIK3CA-related overgrowth spectrum disorder successfully treated with alpelisb.

PIK3CA-related overgrowth spectrum (PROS) encompasses different clinical entities caused by somatic activating mutations in PIK3CA. Among PROS, CLOVES syndrome represents a severe phenotype with poor survival rate. We present the case of a 4-month-old girl with CLOVES syndrome successfully treated with alpelisib, a PIKC3A inhibitor.

Impact of probe sonication and sulfuric acid pretreatment on graphene exfoliation in water.

Graphene is a 2D material with promising commercial applications due to its physicochemical properties. Producing high-quality graphene economically and at large scales is currently of great interest and demand. Here, the potential of producing high-quality graphene at a large scale via water-phase exfoliation methods is investigated.

X-ray Photoelectron Spectroscopy (XPS) Analysis of Ultrafine Au Nanoparticles Supported over Reactively Sputtered TiO Films.

The impact of a titania (TiO) support film surface on the catalytic activity of gold nanoparticles (Au NP) was investigated. Using the reactive dc-magnetron sputtering technique, TiO films with an amorphous, anatase, and nitrogen-doped anatase crystal structure were produced for a subsequent role as a support material for Au NP. Raman spectra of these TiO films revealed that both vacuum and NH annealing treatments promoted amorphous to anatase phase transformation through the presence of a peak in the 513-519 cm spectral regime.

Short-term complications and post-acute sequelae in hospitalized paediatric patients with COVID-19 and obesity: A multicenter cohort study.

Background: Obesity increases the severity of coronavirus disease 2019 illness in adults. The role of obesity in short-term complications and post-acute sequelae in children is not well defined.

Objective: To evaluate the relationship between obesity and short-term complications and post-acute sequelae of SARS-CoV-2 infection in hospitalized paediatric patients.

Synthesis of holey graphene for advanced nanotechnological applications.

Holey or porous graphene, a structural derivative of graphene, has attracted immense attention due to its unique properties and potential applications in different branches of science and technology. In this review, the synthesis methods of holey or porous graphene/graphene oxide are systematically summarized and their potential applications in different areas are discussed. The process-structure-applications are explained, which helps relate the synthesis approaches to their corresponding key applications.

Numerical Study of a Capacitive Graphene Oxide Humidity Sensor with Etched Configuration.

The geometrical dependence of humidity sensors on sensing performance has not been quantitatively outlined. Furthermore, the etching effect on humidity sensors is still elusive due to the difficulty in separating the effects of the geometrical change and etching-induced porosity on the overall performance. Here, we use COMSOL Multiphysics to perform a numerical study of a capacitive graphene oxide (GO) humidity sensor, with emphasis on the dimensions and etching effect on their sensing performance.

Hyperthyrotropinemia is common in preterm infants who are born small for gestational age.

Background To determine the incidence of congenital hypothyroidism (CH) with a delayed increase in thyroid-stimulating hormone (TSH) levels in preterm infants and to describe the associated factors. Methods A prospective newborn screening (NBS) was conducted in 122 very low birth weight (VLBW) premature neonates born between June 2016 and September 2017. A dried blood spot thyroid stimulating hormone (TSH) level ≥15 mIU/L at 7 and 15 days of life, ≥10 in serum at the second screen or ≥5 at the third screen was defined as positive for CH.