Publications by authors named "Monsef Dahman"
Background: Obesity is associated with a chronic and low-grade inflammation which may cause hypoferremia as seen in patients with chronic inflammatory diseases. The aim of the present study was to investigate the relationship between iron status and markers of inflammation in morbidly obese women and the effect of bariatric surgery.
Methods: Our cohort of patients consisted of 178 morbidly obese females selected for bariatric surgery.
Article Synopsis
- Hepcidin is an acute-phase response peptide involved in inflammation and was examined in severely obese patients, particularly those with and without diabetes or nonalcoholic steatohepatitis.
- Hepcidin was found to be expressed in both liver and adipose tissue of obese individuals, with increased levels of mRNA in adipose tissue correlating with inflammation markers like interleukin-6 and C-reactive protein.
- The study concluded that hepcidin acts as a proinflammatory adipokine, contributing to low iron levels during inflammation in obesity.