Discrepancies of assessments in a RECIST 1.1 phase II clinical trial - association between adjudication rate and variability in images and tumors selection.

Background: In imaging-based clinical trials, it is common practice to perform double reads for each image, discrepant interpretations can result from these two different evaluations. In this study we analyzed discrepancies that occurred between local investigators (LI) and blinded independent central review (BICR) by comparing reader-selected imaging scans and lesions. Our goal was to identify the causes of discrepant declarations of progressive disease (PD) between LI and BICR in a clinical trial.

[First experiences with HUNCHEST - low-dose CT lung cancer screening programme].

Introduction: Lung cancer is the cause of death of around 8000 Hungarians each year.

Aim: International studies have proved that low-dose CT (LDCT) screening lowers the lung cancer mortality of high risk patients. The HUNCHEST pilot study launched in 2014 studies the possibilities of a lung cancer screening programme in Hungary.

[New trends and novel possibilities in the radiodiagnosis of lung cancer].

In recent years there have been significant changes in the management of lung cancer. In 2009 a new staging system became effective while in 2011 a new adenocarcinoma classification was introduced. Molecular biology, genetics with hybrid multimodal imaging progressed greatly.

Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative, for the treatment of patients with non-small cell lung cancer.

Purpose: The purpose of this phase I study was to evaluate the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), the recommended dose for phase II study, pharmacokinetics, and antitumor activity of TZT-1,027 (soblidotin) in patients with non-small cell lung cancer (NSCLC) when administered every 3-4 weeks.

Methods: Eligible patients had the following characteristics: stage III/b or IV NSCLC that was refractory to conventional therapy or for which no standard therapy was available; Eastern Cooperative Oncology Group (ECOG) performance status (PS) or=20 and <75 years. The patients were administered TZT-1,027 in escalating doses from 0.

[The importance of CT-guided needle biopsy in the diagnosis of thoracic diseases].

In the report on 35 CT-guided fine needle transthoracic biopsies the authors show the relevance of invasive radiological methods in tumor diagnostics. The results are compared with those published in the literature. CT-guided transthoracic biopsy is of crucial importance in final diagnosis of certain thoracic diseases.

Examination and evaluation of surgical margins in bone tumours. Comparative pre- and postoperative CT and MR imaging.

An objective method of evaluating surgical margins and the extent of limb-preserving surgery is described in a study of 10 malignant bone tumours. The resected specimen was imaged by computerised tomography and magnetic resonance, and the appearances compared with the preoperative images of the tumour. CT was better than MR for detecting bony changes, but MR was more satisfactory for showing the extraosseous and intramedullary outline of the tumour.

[The use of endoprostheses (stents) in airway stenosis].

Six patients with obstruction of the trachea were treated with silicone rubber endothracheal stents implanted with flexible bronchoscope. In every case the stent caused significant clinical improvement of the ventilation. At the postintubation stenosis the stent can result a final recovery, at the malignant processes the implantation seems to be a new palliative method.

Limitations in distinguishing malignant from benign lesions of the breast by systematic review of mammograms.

Our objective was to assess whether or not a systematic review of mammographic descriptors would result in improved classifications of nonpalpable lesions of the breast and reductions of biopsies for benign conditions. The prelocalization mammograms of 200 consecutive patients who had 231 biopsies were reviewed in random order by four radiologists experienced in mammography. Each reader assessed the presence of 32 specific descriptors regarding masses and calcifications.