Publications by authors named "Monnereau A"
Marginal Zone Lymphoma (MZL) comprises three subtypes: extranodal MZL (EMZL), splenic MZL (SMZL) and nodal MZL (NMZL). Since clinical trials have limited representativeness, there is a need for real-world data (RWD) evidence in MZL. Real-world data in Lymphoma and survival in Adults (REALYSA) is a prospective multicentric French cohort of newly diagnosed lymphoma patients.
View Article and Find Full Text PDFReporting tumor genomic test results to SEER registries via linkages.
J Natl Cancer Inst Monogr
August 2024
Article Synopsis
- Precision medicine is increasingly important in cancer care, but tumor genomic data has been lacking in the National Cancer Institute's SEER Program, limiting research on molecular subtypes.
- To improve this, the SEER Program has implemented a centralized process to link cancer cases in their registries with genomic test results from molecular labs, using specialized software and a trusted third party for data handling.
- Recent linkages have included various OncotypeDX tests and results from other genomic classifiers, which facilitate the research community's access to valuable, de-identified data for cancer studies.
Article Synopsis
- The medieval period in Sicily experienced significant regime changes, transitioning from Byzantine to various Muslim rulers, and finally to Normans and Swabians, influencing local communities.
- A multidisciplinary analysis of 27 individuals from neighboring Muslim and Christian cemeteries in Segesta revealed genetic differences but also signs of continuity in diet and social practices.
- Findings indicate that both Muslim and Christian communities coexisted in the 13th century, even as regime changes led to demographic shifts and the establishment of new social relationships.
Article Synopsis
- Advances in lymphoma treatment have made assessing health-related quality of life (HRQoL) crucial for newly diagnosed patients, yet there's limited information on their HRQoL profiles at diagnosis.
- A study involving 3922 adults with various lymphoma types utilized three validated EORTC questionnaires to evaluate HRQoL at diagnosis, achieving high completion rates between 84% and 88%.
- Findings highlighted significant impairments in global health status across lymphoma subtypes, with factors like gender, performance status, and B symptoms affecting HRQoL, providing valuable insights for future research and clinical practices.
Purpose: Three generic claims-based algorithms based on the Illness Classification of Diseases (10th revision- ICD-10) codes, French Long-Term Illness (LTI) data, and the Diagnosis Related Group program (DRG) were developed to identify retirees with cancer using data from the French national health insurance information system (Système national des données de santé or SNDS) which covers the entire French population. The present study aimed to calculate the algorithms' performances and to describe false positives and negatives in detail.
Methods: Between 2011 and 2016, data from 7544 participants of the French retired self-employed craftsperson cohort (ESPrI) were first matched to the SNDS data, and then toFrench population-based cancer registries data, used as the gold standard.
Article Synopsis
- Real-world data (RWD) are crucial for enhancing clinical trial (CT) findings, but challenges like data quality persist; the REALYSA study, launched in 2018, focuses on newly diagnosed lymphoma patients in France.
- A proof-of-concept analysis of 645 patients with diffuse large B-cell lymphoma (DLBCL) found high data completeness (<4% missing) and revealed good survival rates, with a median follow-up of 9.9 months showing 1-year event-free survival of 77.9% and overall survival of 90.0%.
- The study also assessed how well REALYSA's patient outcomes matched those from recent phase 3 trials (POLARIX and SENIOR), demonstrating
Purpose: Some pesticides may increase the risk of certain lymphoid malignancies, but few studies have examined Hodgkin lymphoma (HL). In this exploratory study, we examined associations between agricultural use of 22 individual active ingredients and 13 chemical groups and HL incidence.
Methods: We used data from three agricultural cohorts participating in the AGRICOH consortium: the French Agriculture and Cancer Cohort (2005-2009), Cancer in the Norwegian Agricultural Population (1993-2011), and the US Agricultural Health Study (1993-2011).
Despite the localisation of the southern Caucasus at the outskirt of the Fertile Crescent, the Neolithisation process started there only at the beginning of the sixth millennium with the Shomutepe-Shulaveri culture of yet unclear origins. We present here genomic data for three new individuals from Mentesh Tepe in Azerbaijan, dating back to the beginnings of the Shomutepe-Shulaveri culture. We evidence that two juveniles, buried embracing each other, were brothers.
View Article and Find Full Text PDFArticle Synopsis
- * Findings showed that younger patients with fewer comorbidities had much better access to a Specialized Haematology Unit (SHU), leading to more favorable treatment outcomes compared to older or more severely ill patients.
- * The research concluded that timely access to SHU is crucial for effective diagnosis and treatment of AML, emphasizing the need for improved care pathways, especially for the most deprived patients.
Article Synopsis
- * The study analyzed data from over 10,000 NHL cases and used advanced statistical methods to find 17 significant genetic loci linked to NHL subtypes, including a new one at HHEX.
- * Results show that while there is some shared genetic heritability among NHL subtypes, each subtype has unique genetic characteristics, with varying degrees of genetic correlation between them.
Objectives: Given mixed evidence for carcinogenicity of current-use herbicides, we studied the relationship between occupational herbicide use and risk of non-Hodgkin's lymphoma (NHL) in a large, pooled study.
Methods: We pooled data from 10 case-control studies participating in the International Lymphoma Epidemiology Consortium, including 9229 cases and 9626 controls from North America, the European Union and Australia. Herbicide use was coded from self-report or by expert assessment in the individual studies, for herbicide groups (eg, phenoxy herbicides) and active ingredients (eg, 2,4-dichlorophenoxyacetic acid (2,4-D), glyphosate).
The Oxus Civilisation (or Bactrio-Margian Archaeological Complex, BMAC) was the main archaeological culture of the Bronze Age in southern Central Asia. Paleogenetic analyses were previously conducted mainly on samples from the eastern part of BMAC. The population associated with BMAC descends from local Chalcolithic populations, with some outliers of steppe or South-Asian descent.
View Article and Find Full Text PDFBackground: Sarcomas are rare, heterogeneous, ubiquitously localized malignancies with many histologic subtypes and genomic patterns. The survival of patients with sarcoma has rarely been described based on this heterogeneity; therefore, the authors' objective was to estimate survival outcomes in patients who had sarcomas using the 2020 version of the World Health Organization classification of soft tissue and bone tumors.
Methods: Patients older than 15 years who had incident sarcoma diagnosed between 2005 and 2010 were extracted from 14 French population-based cancer registries covering 18% of the French metropolitan population.
B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS.
Cancer Epidemiol Biomarkers Prev
May 2022
Background: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non-Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes.
Methods: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell-mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression.
Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes.
J Transl Genet Genom
June 2021
Article Synopsis
- * Using data from eight genome-wide association studies, the researchers estimated the fraction of the genome with runs of homozygosity (FROH) and calculated an inbreeding coefficient (F3) to analyze their impact on NHL risk among 3,061 CLL cases, 3,814 DLBCL cases, 2,784 FL cases, and 808
Article Synopsis
- * The research included 507 patients diagnosed between 2006 and 2016, revealing that 22% participated in clinical trials, and overall survival pathways varied while some patients transitioned to second-line treatments or stopped therapy.
- * Despite showing improvements in initial responses for NG-TKI, the study did not definitively conclude that NG-TKI is superior to IM in terms of survival and tolerance, indicating that further research is necessary. *
Article Synopsis
- A study examined the link between occupational insecticide use and non-Hodgkin lymphoma (NHL) risk, analyzing data from 9 case-control studies across various regions with nearly 8,000 cases and 8,600 controls.
- Overall, occupational insecticide use was not linked to NHL, but specific types, like organophosphates and carbaryl, showed increased risk for all NHL and certain subtypes.
- The findings highlight the need for public health agencies to consider the risks associated with continued use of organophosphate and carbamate insecticides based on the evidence gathered.
Objective: To analyze trends in cancer incidence and mortality (France, 1990-2018), with a focus on men-women disparities.
Methods: Incidence data stemmed from cancer registries (FRANCIM) and mortality data from national statistics (CépiDc). Incidence and mortality rates were modelled using bidimensional penalized splines of age and year (at diagnosis and at death, respectively).
Article Synopsis
- - Incidence rates of hematological malignancies have been rising over the past 40 years alongside increased usage of agricultural pesticides, yet research on the link between pesticide exposure and these cancers in the general population remains limited.
- - A systematic review was conducted analyzing 23 studies, including various types of research designs, which found positive associations between certain pesticides and the risk of hematological malignancies, particularly in studies focused on children.
- - Despite the suggested connection between pesticide exposure and increased cancer risk, the literature shows significant variability in study relevance and exposure assessment methods, indicating a need for more rigorous future research.
Non-Hodgkin lymphomas (NHL) are underestimated causes of cancer in West Africa where chronic viral hepatitis and HIV are endemic. While the association with HIV infection has already been characterized, limited information is available on the association between chronic viral hepatitis and NHL in sub-Saharan Africa. A case-control study was conducted in referral hospitals of Abidjan (Cote d'Ivoire) and Dakar (Senegal).
View Article and Find Full Text PDFObjectives: More than half of cancer patients require palliative care; however, inequality in access and late referral in the illness trajectory are major issues. This study assessed the cumulative incidence of first hospital-based palliative care (HPC) referral, as well as the influence of patient-, tumor-, and care-related factors.
Study Design: This is a retrospective population-based study.
Background: Age-adjusted lymphoma incidence rates continue to rise in France since the early 80's, although rates have slowed since 2010 and vary across subtypes. Recent improvements in patient survival in major lymphoma subtypes at population level raise new questions about patient outcomes (i.e.
View Article and Find Full Text PDFBackground: Cancer-incidence and mortality-trend analyses require appropriate statistical modelling. In countries without a nationwide cancer registry, an additional issue is estimating national incidence from local-registry data. The objectives of this study were to (i) promote the use of multidimensional penalized splines (MPS) for trend analyses; (ii) estimate the national cancer-incidence trends, using MPS, from only local-registry data; and (iii) propose a validation process of these estimates.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on the outcomes of metastatic colorectal cancer (mCRC) patients with different RAS and BRAF mutation statuses who were treated with cetuximab.
- The EREBUS cohort included 389 patients; results showed that those with RASwt/BRAFwt had the best survival rates, while RASwt/BRAFmt patients fared worse.
- Findings indicate that BRAF mutations significantly worsened progression-free survival (PFS) and overall survival (OS) for patients treated with cetuximab, emphasizing the importance of genetic testing in treatment planning.