Effects of on neuropathic pain induced by chronic constriction injury to sciatic nerve of Wistar rat.

Objective: The research was designed to assess the consequences of aqueous leaf extract (AILE) neuropathic pain in Wister rats and the role of the ATP-dependent potassium channel (K) as an underlying mechanism.

Materials And Methods: This experimental layout was conducted on Wistar rats ( = 120) having 150 to 200 gm of body weight. On the foundation of the experimental design, rats were divided into group I (normal saline, 5 ml/kg/body weight) and group II (sham surgery and treatment with NS), group III [chronic constriction injury (CCI) in the sciatic nerve; and treated with NS], group IV (CCI and treated with AILE 400 mg/kg body weight), Group V (CCI, pretreated with Glibenclamide 15 mg/kg followed by treated with AILE 400 mg/kg).