Publications by authors named "Monira Begum"
Article Synopsis
- The SARS-CoV-2 Omicron BA.2.75 variant, emerging in May 2022, is a distinct descendant of BA.2 and shows a greater reproductive number than the dominant BA.5 variant.
- BA.2.75 demonstrates different responses to vaccines and antibodies, retaining antiviral drug effectiveness but showing variable antibody sensitivity due to unique genetic changes.
- This variant has enhanced ability to bind to human receptors, increased growth efficiency in lung cells, and heightened pathogenicity in hamsters, indicating a potentially greater risk to global health compared to BA.5.
Background: Hemolytic uremic syndrome (HUS) may complicate up to 15% of cases of Shiga toxin (Stx)-expressing enterohemorrhagic Escherichia coli (STEC) O157:H7 infections in children. Administration of antimicrobials has been reported to increase the risk of STEC-associated HUS by >10-fold, presumably by increasing the expression and release of Stx by dying STEC bacteria. Shigella dysenteriae type 1 also expresses Stx.
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